A series of new biologically interesting furoxan-3-thiazolidinones have been synthesized via onepot three-component reaction of furoxan aldehydes, anilines and mercaptoacetic acid. The multicomponent reaction involves condensation of furoxan aldehyde with aniline to give imine; the formed imine undergoes nucleophilic addition with mercaptoacetic acid, followed by cyclisation with loss of H2O to obtain the desired products. All the synthesized compounds were well characterized using spectral techniques and confirmed by an X-ray crystal structure for one compound.