In recent times, anion transporters have accomplished substantial consideration due to their ability to disrupt ionic equilibrium across the membrane bilayers. While numerous Cl─ ion transporters were developed for channelopathies,...

Retrieval of depleting resources from wastewater could resolve its mounting demands in our society. Phosphate is an essential nutrient for all living things. However, the diminution of global reserves of...

Palladium is a key element in fuel cells, electronic industries, and organic catalysis. At the same time, chromium is essential in leather, electroplating, and metallurgical industries. However, their unpremeditated leakage into aquatic systems has caused human health and environmental apprehensions. Herein, we reported the development of an sp2 carbon‐conjugated fluorescent covalent organic framework with a guanidine moiety (sp2c‐gCOF) that showed excellent thermal and chemical stability. The sp2c‐gCOF showed effective sensing, capture, and recovery/removal of Pd(II) and Cr(VI) ions, which could be due to the highly accessible pore walls decorated with guanidine moieties. The fluorescent sp2c‐gCOF showed higher selectivity for Pd(II) and Cr(VI) ions, with an ultra‐low detection limit of 2.7 and 3.2 nM, respectively. The analysis of the adsorption properties with a pseudo‐second‐order kinetic model showed that sp2c‐gCOF could successfully and selectively remove both Pd(II) and Cr(VI) ions from aqueous solutions. The polymer also showed excellent capture efficacy even after seven consecutive adsorption‐desorption cycles. Hence, this study reveals the potential of fluorescent sp2c‐gCOF for detecting, removing, and recovering valuable metals and hazardous ions from wastewater, which would be useful for economic benefit, environmental safety, human health, and sustainability. The post‐synthetic modification of sp2c‐COF with suitable functionalities could also be useful for sensing and extracting other water pollutants and valuable materials from an aqueous system.

The unprecedented cases of antimicrobial resistance and scarcity of effective antibiotics against resistant strains demand the development of proficient antibiotics and their stewardship. The antibiotic carriers and the adjuvants that can counteract the resistance mechanism and revive the activity of existing antibiotics are considered as one of the promising tools to fight against antimicrobial resistance and its consequences. Herein, we demonstrated the development of sulfonium- and lauryl amine-conjugated BSA protein nanoparticles (PNPs) with inherent antimicrobial activities that embraced the benefits of biocompatibility and antibiotic-carrying capability. The PNPs showed encapsulation and controlled release profiles of clinically approved antibiotics. The antibiotic-encapsulated PNPs exhibited synergistic antimicrobial activity against Gram-negative, Gram-positive, and drug-resistant bacterial strains, which could reduce the effective doses of antibiotics and exposure to other microbial strains. Subsequent studies showed that the PNPs were capable enough to breach the sturdy biofilm barriers of the bacterial strains, and at a minimum inhibitory concentration, the biofilm lost its viability. The antibiotic-encapsulated PNPs also lower the drug resistance ability of commercial antibiotics. The mechanistic studies revealed that the antibacterial activity of the PNPs follows a membrane-directed pathway. The PNPs showed negligible toxicity against erythrocytes. Interestingly, lauryl amine and sulfonium-conjugated albumin protein (R-BSA-S) gives protection against Staphylococcus aureus biofilm-associated infection in albino laboratory-bred (BALB/c) mice, as appeared from the decrease in the colony forming unit (CFU) count and histological changes in the liver and spleen. Thus, the synthesized antimicrobial carrier molecule revitalizes the activity of the antibiotics and is a cost-effective strategy.