Introduction: Upper gastrointestinal pathology is one of the causes for gastrointestinal mortality and morbidity. The histopathological study of endoscopic biopsies from the upper gastrointestinal tract helps to permit early and exact diagnosis of the existing disease and also in further management of patients. Aim and Objectives: The present study is done to analyse the prevalence of various upper gastrointestinal lesions received in our institution and their histopathological findings for early diagnosis which helps in better patient management. Materials and Methods: A study was conducted in all upper gastrointestinal endoscopic biopsies received in our hospital from June 2016 to May 2017. The patient of all ages and both sexes who underwent endoscopic biopsy was included and analysed on haematoxylin and eosin stained sections. Results: A total of 259 cases were studied. Patient's age ranging from 21 to 74 years was taken. Males were more prevalent. Stomach was the commonest site of endoscopic biopsies. The histopathology revealed non-neoplastic lesions 173 (66.80%) and neoplastic lesions 86 (33.20%). Most common nonneoplastic lesion was 51 cases of chronic non specific gastritis. In neoplastic lesions of stomach, adenocarcinoma was the commonest. Conclusions: Endoscopic procedure along with histopathological interpretation still remains as a mainstay of diagnostic modality. So Histopathology is considered as gold standard for the diagnosis of endoscopically detected lesions which helps in early detection of mucosal lesions, both benign and malignant. Histopathology acts as a powerful diagnostic tool in better management and survival of patients.

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Background: Diagnosis of soft tissue tumors is a great challenge to pathologist but with the help of immunohistochemistry (IHC), proper analysis and diagnosis of soft tissue tumours can be made easy. The main use of immunohistochemistry in soft tissue neoplasms especially in sarcomas is to identify differentiation in the neoplastic cells.IHC are used as a panel or as single marker depending on the tumor. Methods:A total of 513 soft tissue tumor (STT) cases were collected and reviewed. The cases were separated into as benign, intermediate and malignant cases. In 90 cases of STT in which immunohistochemistry (IHC) were used was further analysed and classified depending on the various positivity and negativity of the marker used .The significance of IHC was also analysed. Result:In our study of 513 cases of STT there were 380 benign cases, 90 malignant cases and 43 intermediate cases. A total of 90 cases of sarcomas were present out of which 54% cases required IHC, 20 % cases required IHC to support the diagnosis but 26% of cases did not require IHC, the diagnosis was made on haematoxylin and eosin (H&E). The IHC markers helped in correct diagnosis of STT cases. Conclusion:Immunohistochemistry plays an important role in grading and giving precise diagnosis of soft tissue tumors. So it is important to use IHC to diagnose STT where haematoxylin and eosin did not give a precise diagnosis. Perfect diagnosis of STT helps in the correct therapeutic management of patients.