Background: Histological grading is the most important prognostic factors and the best indicator of metastatic risk in adult soft tissue sarcomas. It has been shown that Ki67 immunohistochemical (IHC) staining is an effective method of assessing the prognosis in a number of tumor types. Ki67 is a cell cycle antigen which is elevated in proliferation states. High level of Ki67 expression is an independent prognostic indicator that correlates with poor outcome in patients with sarcomas. Methods:In this study 53 cases of soft tissue tumor were selected and were classified according to FNCLCC system. IHC staining of Ki-67 was done in all the 53 samples. Diagnosis was made mainly based on histopathological pattern analysis and with the use of IHC.Results: By using FNCLCC grading soft tissue tumor cases were graded as grade I, II and III. The correlation between the FNCLCC grading and Ki67 was done and it was observed that there was statistically significant positive correlation between Ki67 and the grade of the tumor, as evidenced by P-values of 0.002, 0.005 and 0.004. The correlation between the FNCLCC grading and Ki67 index was also assessed. Statistically significant positive correlation between Ki67 index and the grade of the tumor was observed. Conclusion:There was significant correlation noted between FNCLCC grading and Ki-67 index. Thus it can be recommended that Ki-67 IHC stain should be done on routine basis to accurately grade the sarcomas so that it will be beneficial for the management of the patient.

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Introduction: Skin is the largest organ of our body. Non-neoplastic skin lesions are more common than neoplastic lesions. The histopathological study was done to know the prevalence of various non-neoplastic skin lesions of patients who attended the outpatient department of dermatology over a period of three years from Jan 2016-Dec2018. Materials and Methods: In this study total of 209 cases of skin lesions were taken over a period of three years. The diagnosis of these skin lesions was confirmed by histopathological examination with routine hematoxylin and eosin stain. Results: A total of 209 cases of non-neoplastic lesions were taken for the study. Out of these lesions, 63 cases (30.14 %) were non-infectious-vesiculobullous, 54 (25.84 %) were reported under the category of infectious etiology, 41 cases (19.62 %) of non-infectious erythematous papulosquamous diseases, 13 cases (6.22 %) of inflammatory disorders, 10 (4.78%) cases showed connective tissue disorders. 8(3.83%) cases were reported as vasculitis and 2 cases (0.96) of fungal origin. 18 cases come under the miscellaneous category that was correlated clinically and were treated. Conclusion: In the present study of non-neoplastic skin lesions, non-infectious vesiculobullous diseases were more common. Pemphigus Vulgaris was the most common lesion. The non-neoplastic skin lesions were most commonly seen in males than females in our population of the study.