Prevailing personal mobile network architectures make use of streamlined mobility control system, where the complete understanding is concentrated on single-end that results in scarce of dynamic mobility support when data volume is found to be large. The present-day networks necessitate seamless connections regardless of node position and connectivity that has to be accomplished between personal are network (PAN). In this work, a novel method called, Markov Renewal Prediction and Radial Kronecker Neural Network (MRP-RKNN) based optimized handover for seamless mobility in PAN is proposed. By employing a Markov Renewal Prediction model for Seamless Mobility along with the two-hop network architecture, in this paper, we propose a transition probabilities (TP) function to mitigate the persistent handover issue in conventional wireless communication systems. The proposed Markov Renewal Prediction model for Seamless Mobility significantly reduces handover execution time and seamless mobility handover accuracy with efficient transition probabilities. In PANs, the unavoidable deployment of low power sink nodes permits the mobile nodes with many issues in terms of Quality of Service (QoS) due to complication of recurrent handovers due to high mobility. Addressing this issue of handover optimization in the deployment of PAN, this work proposes a model called to optimize the handovers in a cost-efficient manner. In this work, Radial Kronecker Delta Neural Network is utilized for handling frequent handovers based on received signal strength and cost metrics. Here, the resultant desired output is obtained using the Radial Kronecker function being a function of two variables with which optimized handover is performed. Simulation results presented in the study exhibits the performance and prediction rate of the proposed method in terms of handover execution time, seamless mobility prediction accuracy, mobility handover cost and packet loss rate.