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The competence of benzophenone analogues as chemotherapeutic agents, especially as anti-inflammatory and antifungal 1 compounds, is well recognized. Recently, the synthesis and structure-activity relationship of benzophenones as a novel class of p38 MAP kinase inhibitors with high anti-inflammatory activity were reported. 2 The presence of various substituents on the benzophenone nucleus is crucial in determining the quantitative structure-activity relationships. Investigations were carried out to show that methyl-substituted benzophenones exhibit anti-fungal activity. In view of the above, and in order to study the molecular conformation, the title compound was synthesized. Its crystal structure is reported here. A schematic diagram of the molecule is shown in Fig. 1.A solution of anhydrous aluminum chloride (3.2 g, 0.02 mol) in dry nitrobenzene (25 ml) was added to 2-methylphenyl-4-methylbenzoate (5 g, 0.022 mol) dissolved in nitrobenzene (10 ml), the mixture being protected from moisture by a calcium chloride guard tube and refluxed with stirring for 30 min. At the end of this period the solution was cooled and decomposed by acidulated ice-cold water. The nitrobenzene was removed by steam distillation. The residual solid was crushed into a powder, extracted with 10% sodium hydroxide (3 × 50 ml). The basic aqueous solution was neutralized with 10% hydrochloric acid. The product was extracted into ether and the ether layer was washed well with a saturated sodium chloride solution. Evaporation of the ether after drying over anhydrous sodium sulfate, followed by recrystallization from alcohol gave the title compound in 85% yield.A single crystal of the title compound with dimensions 0.3 × 0.27 × 0.25 mm was chosen for an X-ray diffraction study. The details of the crystal and refinement data are given in Table 1.The data were collected on a DIPLabo Image Plate system with graphite-monochromated Mo Kα radiation. Thirty six frames of data were collected by the oscillation method. Each exposure of the image plate was set to a period of 400 s. Successive frames were scanned in steps of 5˚ per min with an oscillation range of 5˚. Image processing and data reduction were performed using Denzo. 3The reflections were merged with Scalepack. All of the frames could be indexed using a primitive monoclinic lattice. The title compound, C15H14O2, was synthesized and the structure was studied by X-ray crystallography. The compound crystallizes in monoclinic crystal class in the space group P21/n with cell parameters a = 5.9910(5)Å, b = 13.493(2)Å, c = 14.894(2)Å, β = 95.776(8)˚ and Z = 4. The structure exhibits intermolecular hydrogen bonds of the type O-H·O.

The N-heterocycles are of considerable importance in view of their presence in several biological systems. Benzimidazole derivatives and their metal complexes exhibit anti-bacterial, veterinary, anti-helmintic, insecticidal and virucidal activities. 1 Multidentate N-heterocycles produce organized supramolecules on coordination to metal ions and they appear quite promising for the design of stable light conversion devices. 2In this direction, some of the multidentate N-heterocycles and their complexes have been prepared and characterized. As part of our continuing research in the field of syntheses of nitrogencontaining heterocyclic ligands and their metal complexes with palladium and rhodium, 3 we are reporting here the synthesis and crystal structure of 6-pyridyl-5,6-dihydrobenzo [4,5]The synthesised ligand was characterized by physical, spectral and single crystal X-ray structural analyses.o-Aminophenylbenzimidazole (0.05 mol: 10.45 g) was dissolved in 200 ml of alcohol. To this, 2-pyridylinaldehyde (0.05 mol; 4.75 g) was added, and the mixture was refluxed for 4 -5 hours. The chemical structure is as shown in Fig. 1. A yellow compound was obtained. It was concentrated under reduced pressure. The solid was recrystallized from methanol to get a pure compound. A suitable crystal for X-ray analysis was grown by the slow evaporation method using methanol as solvent.A single crystal of the title ligand of dimensions 0.2 × 0.4 × 0.5 mm was chosen for X-ray diffraction studies. The measurements were made on a Rigaku AFC7S diffractometer with graphite-monochromated radiation (Mo Kα). The data were collected using the ω-2θ scan technique and reduced using the teXsan data reduction program. 4 Lorentz and polarization corrections were applied. The structure was solved by direct methods and refined by a full-matrix least squares method with anisotropic temperature factors for the non-H atoms. All the H atoms were placed at chemically acceptable positions and were refined with isotropic temperature factors. The experimental crystallographic details are given in Table 1.The final coordinates and equivalent thermal parameters of non-H atoms are listed in Table 2. Table 3 gives the bond distances and angles of non-hydrogen atoms. The bond distances and bond angles are in good agreement with the standard values. The title compound C19H12N4 was synthesised and the structure was investigated by X-ray crystallography. It crystallizes in the monoclinic space group P21/c with cell parameters a = 8.697(9)Å, b = 13.045(10)Å, c = 13.271(4)Å, β = 97.38(4)å nd Z = 4. The final residual factor is 0.0628.

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The chemistry of condensed heterocycles, such as the 1,2,4triazolo thiadiazole ring, occupies an extremely important niche within the family of 5 and 6 membered ring heteroaromatics. They play a central role in numerous molecules of established bioactivities, which includes fungicidal, insecticidal, bactericidal, 1 herbicidal, anti-tumor, anti-inflammatory, CNS stimulant 2 properties. They also find applications as dyes, lubricants and analytical reagents. A triazolo-thiadiazole system may be viewed as a cyclic analog of two very important components-thiosemicarbazide and biguanide, which often display diverse biological activities. Therefore, it is worthwhile to investigate the system of combining these three biologically active components in a compact system for screening of their biological activities. In view of the above, we herein report on the synthesis and crystal structure of the title compound. We synthesized the compound, 4-amino-3-(p-tolyl)-5mercapto-[1,2,4]-triazole using one of the reported procedures. 3 The second set of syntheses involves an efficient one-pot method, where the condensation of 4-amino-3-(p-tolyl)-5mercapto-[1,2,4]-triazole with 4′-methyl-biphenyl carboxylic acid under different conditions including microwave irradiation in the DMF solvent and 3-substituted-6-(4′-methyl-biphenyl-2yl)-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazoles. The condensation was carried out as shown in either POCl3 at reflux temperature for overnight or with para-toulene sulfonyl chloride in toulene for 12 h at 65-70˚, or microwave irradiation (Kenstar) in DMF as a solvent for about 30-40 s at 60% power. A schematic diagram of the molecule is shown in Fig. 1. The crystal and experimental details are given in Table 1. A single crystal of the title compound with dimensions of 0.3 × 0.27 × 0.25 mm was chosen for an X-ray diffraction study. The data were collected on a DIPLabo Image Plate system with graphite monochromated Mo Kα radiation. Thirty six frames of data were collected in oscillation mode with an oscillation range of 5˚, and processed using Denzo. 4 The reflections were merged with Scalepack. Table 2 gives selected bond lengths and bond angles of the non-hydrogen atoms. The structure was solved by direct methods using SHELXS-97. The structure was refined by a fullmatrix least-squares method with anisotropic temperature factors for non-hydrogen