Anticancer therapy has the potential to cause unwanted cardiovascular side effects. Utilization of radiation therapy to treat tumors near the heart can result in radiation-induced valvular heart disease among other cardiovascular pathologies. The aim of this review is to describe the epidemiology, pathophysiology, risk prediction, non-invasive imaging modalities and management of radiation-induced valvular heart disease with a focus on pre-operative risk assessment and contemporary treatment options.
Cushing syndrome is a rare cause of dilated cardiomyopathy and heart failure with reduced ejection fraction. Cases describing this association are scarce. We describe a patient presenting with acute heart failure, new cardiomyopathy, refractory hypokalaemia, severe hyperglycaemia, and uncontrolled hypertension who was found to have hypercortisolism secondary to an ectopic adrenocorticotropic hormone-secreting primary lung neoplasm. This case highlights the effects of hypercortisolism on the myocardium. The finding of a non-dilated cardiomyopathy in this case is unique because the majority of previously reported Cushing syndrome cardiomyopathy cases have described left ventricular dilatation or significant left ventricular hypertrophy. In addition, small-cell lung cancer with adrenocorticotropic hormone production causing Cushing syndrome cardiomyopathy is rare.
perceived the Moses setting in 57.7% of cases compared to 48.6% of cases without Moses. After using Moses, surgeons experienced less mental burden, physical burden, temporal demand, frustration, and less required effort. Perception of operative performance was higher when using the Moses setting. These findings remained significant on multivariable analysis.CONCLUSIONS: No significant differences were seen in total operative time, ureteroscopy time nor stone-free rate. However, use of Moses settings remained a significant predictor across NASA task load domains after controlling for factors that increase surgeon workload during ureteroscopy.
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