OBJECTIVE OF THE STUDY:To compare the effectiveness of two different doses of Dexmedetomidine, 0.6μg/kg body weight and 1μg/kg body weight in attenuating haemodynamic response to laryngoscopy and endotracheal intubation. MATERIAL AND METHODS: 90 ASA Class 1 patients posted for elective surgery divided into 3 groups, Group DX-0.6 receive Dexmedetomidine, 0.6μg/kg body weight Group DX-1 receive Dexmedetomidine, 1μg/kg body weight and Group CT receive normal saline. The HR, SBP, DBP, MAP recorded at different intervals. OBSERVATIONS: There was a decrease in mean HR in group DX-0.6 and group DX-1 (p=0.000) when compared to group CT at 1 st , 5 th and 10 th minutes after intubation and showed a fall in SBP in group DX-0.6 and group DX-1 at 2 nd min, 5 th min and 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean SBP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared group CT (p=0.000). Significant fall in DBP in group DX-0.6 and group DX-1 at 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean DBP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared to group CT (p=0.000). A fall in MAP in group DX-0.6 and group DX-1 at 2 nd min, 5 th min and 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean MAP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared to group CT(p=0.000). CONCLUSION: Dexmedetomidine -0.6µg/kg body weight and 1µg/kg body weight are equally efficacious in obtunding the haemodynamic responses to laryngoscopy and endotracheal intubation. KEYWORDS: Different doses of dexmeditomedine, laryngoscopy, intubation. BACKGROUND:Dexmedetomidine in the dose of 0.6µg/kg body weight 1-3 and 1µg/kg body weight 4-7 as intravenous bolus for attenuating the haemodynamic response. There are conflicting reports as to which dose of the drug is idealy to suppress the intubation response and also have minimal adverse effects. So, the present study is aimed at comparing the effectiveness of two different doses of intravenous Dexmedetomidine, 0.6µg/kg body weight and 1µg/kg body weight for attenuating haemodynamic response to laryngoscopy and endotracheal intubation.