Background: One of the greatest challenges that will face by the health system globally in the 21stcentury will be the increasing burden of chronic kidney diseases. Self-care management becomes an inevitable and significant task for them. Aim: The aim of the study was to assess the effectiveness of VAT with reinforcement handbook on knowledge patient and their self-care behavior among hemodialysis. Methods: An evaluative approach with one group pretest post -test design was adopted for the study. The study was conducted in SVBCH, Silvassa among 70 hemodialysis patients using convenience sampling method. Results: The results of the study revealed that the posttest mean knowledge scores of patient(18.6), and the self-care behavior of patients(111.5) found higher that the pretest mean(13.1, and 103.6) scores and the obtained ‘t’ values (patient- 11.02, patient’s self-care behavior-7.99, were greater than the table value 1.995 and it found to be highly significant at p<0.05. Hence the intervention was effective in improving knowledge and self-care behavior. The knowledge scores and the self-care behavior scores of hemodialysis patients found positively correlated (0.3). There was a significant association between hemodialysis patient pretest knowledge & educational status. There was no significant association between patient pretest self-care behavior & selected demographic variables. Conclusion: The study results confirmed that the knowledge regarding self-care management of hemodialysis patient significantly increased among patients after administration of video assisted teaching with reinforcement handbook. Self-care behavior also increased among patients along with the knowledge of patients.