Aim:The study reports of Chryseobacterium indologenes are limited in India. Hence, we retrospectively investigated the underlying diseases in patients in whom we isolated this organism and studied the antimicrobial resistance pattern. Background: C. indologenes is a rare pathogen in humans and is not normally present in the human microflora although it is widely distributed in nature. It shows a multidrug resistance pattern which makes the treatment challenging for the clinicians. Description: Patients with C. indologenes were identified in our hospital between January 2016 and August 2017. Clinical features and antimicrobial susceptibilities of these patients were analyzed. Five isolates of C. indologenes were identified, with all the patients having underlying diseases. C. indologenes were isolated from endotracheal secretions, blood, pleural fluid and hemodialysis catheter tip. Majority patients had other co-morbidities. Out of 5 isolates, 3 isolates were pandrug resistant for our selected panel of drugs. Conclusion: C. indologenes are shown to be resistant isolates to multiple antibiotics, making the treatment challenging for the clinicians. However, the outcomes of the patients remain favorable. Although resistance was high, virulence is not very high.