Objective: To detect potential adverse effects of aqueous extract of Labisia pumila var. alata (LPE) or `Kacip Fatimah' on the estrous cycle, reproductive performance, post-natal growth and offspring survival of rats. Department of Pharmacology, Materials and Methods: Forty eight (48) female Sprague Dawley rats with consecutive School of Medical Sciences, 4 to 6 days estrous cycle were given distilled water (as control) or LPE at 2, 20, 200, 400 *School of Health Sciences, or 800 mg/kg daily by gavaging ten days prior to mating, mating (a maximum period of Universiti Sains Malaysia Health ten days), gestation and lactation periods of seven days. Dams and fetuses were sacrificed Campus, 16150 Kubang Kerian, on day seven postnatal. Kelantan, Malaysia Results: Labisia pumila extracts did not alter the estrous cycle and general health of all