The performance of treating the cardiac diseases is dependent on the kind of drug being selected. There exist numerous decisive support systems which work according to certain characteristics and factors like drug availability, and popularity. Still, they struggle to achieve expected performance in supporting the medical practitioner. To handle this issue, a multi feature drug curing rate based drug compound selection and recommendation system (MDCRSR) is presented. The method utilizes medical histories and data set of various medical organization around the disease considered. Using the traces, the method identifies the drug compounds and features to perform preprocessing which eliminates the noisy data points. Further, the features of the traces are extracted to perform training with genetic algorithm. At the test phase, the method estimates the fitness measure for different drug combination and compounds by measuring their Drug Curing Rate (DCR). The method performs cross over and mutation to produce various populations of drug compounds. According to the curing rate, the drug compound pattern or population is selected and ranked. The ranked results are populated to the medical practitioner. The method improves the performance of recommendation system as well as drug compound selection.