Patients enrolled in the PMTTCC had improved tobacco abstinence rates at 6 months compared to SOC. Although the study was not designed to test for causality, the results lend support for using intensive tobacco cessation management in veteran population.

The COVID-19 global pandemic imposed many challenges to healthcare systems. Integrated health agencies deployed their own strategies to accommodate the drastic changes; however, the perspectives of essential workers in these settings are scant. This study focused on understanding how integrated health agencies responded to the pandemic in its earlier months from the perspectives of social workers providing services in these settings, as they are instrumental to the delivery of behavioral health care. A qualitative study was conducted using constant comparison analysis and the data interpreted from a social constructivist approach. Four main themes emerged: pandemic impact on continuity of service delivery, services, patient interaction, and areas of improvement. Findings from this study can assist in understanding how unique healthcare settings with a systematic coordination of general and behavioral health care responded to the COVID-19 pandemic crisis, and highlights opportunities to improve preparedness for future similar events.

Insulin resistance has been linked to increased risk of stroke recurrence, death, and poor outcome following stroke. Insulin resistance, a common phenomenon following stroke, is associated with elevated levels of insulin circulating in the periphery, which leads to brain insulin deficiency. Brain insulin promotes neuroplasticity and synaptogenesis, has anti-inflammatory, anti-thrombotic, vasodilatory, and anti-apoptotic properties. The impact of brain insulin deficiency and the therapeutic potential of increasing brain insulin levels has yet to be fully understood. Hence, purpose of this study is to assess the potential therapeutic benefits of intranasal insulin treatment on stroke outcomes in a mouse model of brain insulin deficiency. Ischemic stroke was induced using a 30 minute middle cerebral artery occlusion (MCAO) in 16 week old (12 week diet) male and female mice on either a standard diet (control) or a high-fat diet induced at 4 weeks of age, a model of brain insulin deficiency. Recovery assessments begin on day 0 following stroke and continue until day 14 post stroke. Recovery assessments entail observing survival, neurological, motor, and cognitive function after receiving either intranasal saline (0.9%) or intranasal insulin (1.75 U). These assessments were evaluated by survival, and completion of the neurological severity score, ladder, and problem solving tasks on days 0-14 post stroke. High-fat diet-induced brain insulin deficiency was associated with worse survival and neurological deficits following ischemic stroke, intranasal insulin improved stroke mortality and neurological assessments in high-fat diet mice. Thus, intranasal insulin may be a useful therapy for improving stroke outcomes.