The effects of 10 different extracts of fruits and berries on cell proliferation of colon cancer cells HT29 and breast cancer cells MCF-7 were investigated. The fruits and berries used were rosehips, blueberries, black currant, black chokeberries, apple, sea buckthorn, plum, lingonberries, cherries, and raspberries. The extracts decreased the proliferation of both colon cancer cells HT29 and breast cancer cells MCF-7, and the effect was concentration dependent. The inhibition effect for the highest concentration of the extracts varied 2-3-fold among the species, and it was in the ranges of 46-74% (average = 62%) for the HT29 cells and 24-68% (average = 52%) for the MCF-7 cells. There were great differences in the content of the analyzed antioxidants in the extracts. The level of the vitamin C content varied almost 100-fold, and the content of total carotenoids varied almost 150-fold among the species. Also in the composition and content of flavonols, hydroxycinnamic acids, anthocyanins, and phenolics were found great differences among the 10 species. The inhibition of cancer cell proliferation seen in these experiments correlated with levels of some carotenoids and with vitamin C levels, present at levels that can be found in human tissues. The same inhibition of cell proliferation could not be found by ascorbate standard alone. This correlation might indicate a synergistic effect of vitamin C and other substances. In MCF-7 cells, the anthocyanins may contribute to the inhibition of proliferation.

The annual Corruption Perceptions Index (CPI), published by Transparency International (TI), has had a pivotal role in focusing attention on corruption. Despite recent critiques of the CPI, it remains highly influential on research into the causes of corruption and is also extensively used to galvanise support for measures to fight corruption. In this article we explore the CPI in more depth in order to highlight how the index has been used for political ends which may not always turn out to be supportive of anti-corruption efforts. The argument is developed in four sections: in the first, we focus on Transparency International's definition of corruption, highlighting some conceptual difficulties with the approach adopted and its relationship to the promotion of 'good governance' as the principal means of combating corruption. In the second section, we outline some methodological difficulties in the design of the Corruption Perceptions Index. Although the CPI has been much criticised, we demonstrate in the third section that the index continues to exercise great influence both in academic research and in the politics of anti-corruption efforts, particularly as exercised by Transparency International itself. In the final section we argue that the CPI contributes to the risk of creating a 'corruption trap' in countries where corruption is deeply embedded, as development aid is increasingly made conditional on the implementation of reforms which are impossible to achieve without that aid. P O L I T I C A L S T U D I E S : 2 0 0 9 VO L 5 7 ,

Four cultivars of sea buckthorn berries were analyzed for their carotenoid and chlorophyll contents during ripening in three consecutive years. The different carotenoids generally increased in concentration during ripening and comprised from 120 to 1425 microg/g of DW of total carotenoids (1.5-18.5 mg/100 g of FW) depending on cultivar, harvest time, and year. GLM analyses revealed the effect of cultivar to be considerably larger than that of year and harvest time. The content of pheophytin a, a chlorophyll a derivate, steadily decreased during berry ripening. Pheophytin a therefore acted as a marker of the degree of ripening of sea buckthorn berries and was used here to convert harvest date into an estimated ripening time.

Black currant berries contain many biochemical compounds with proven or potential human health benefits. We studied the content of total and single polyphenols, ascorbic acid, soluble sugars, and titratable acidity for two advanced selections and three cultivars of black currant at two distant locations in Sweden (south: 56°06'N; north: 65°21'N) over a 3 year period. Regression analyses revealed the effect of genotype to be considerably larger than that of location and year. However, significant effects of location, year, and interactions were also revealed. A principal component analysis nevertheless separated the genotypes. The content of ascorbic acid, total phenols, total anthocyanins, and soluble sugars was highest in berries from the south, whereas the content of phenolic acids and titratable acidity was highest in berries from the north. The results show that selection of cultivars and production sites are important for cultivation of high-quality black currant raw material for health-promoting products.