The review article presents data on the features of psychosomatic disorders that contribute to the development of infertility among married couples. Socio-psychological features of reproductive setting of infertile men and women, peculiarities of self-perception and female self esteem in infertile marriages, general identity of women who suffer from infertility, reasons of psychological unreadiness to maternity.The causes of psychological infertility are revealed, which should be search not only from women, but also among men. The importance of psychotherapy in the treatment of this pathology is highlighted. In the general structure of the reproductive sphere, the physiological and psychological components are interrelated. This means that women with a history of infertility have certain psychological problems that complicate the formation of readiness for pregnancy and motherhood. These can be fears, anxieties related to family history, personal experience of a woman, her individual personal qualities or features of the current life situation (relationship with a partner and other loved ones, alternative life values, financial problems), which manifests itself in unconscious resistance , is realized in somatic form. Infertility leads to the negative changes in the structure of woman’s psycho emotional state, self esteem and social well-being of couple and can cause breach in family relationship. That is why it is recommended to pass complex examination, which includes first of all psycho diagnostic of psycho emotional sphere of individual.

The aim: To analyze the main types of intrauterine infections(IUI), their routes of transmission and features of the clinical picture, as well as the influence of pathogens on the course of pregnancy. Materials and methods: Data review of native and foreign literature published over the past 5 years. Conclusions: Summing up, it should be noted the role of infections in the pathogenesis of pathological conditions that form in the perinatal period. This is evidenced by numerous works on the problem of CBS. The most significant perinatal risk factors for fetal infection have been identified. It is proved that in the development of infectious lesions of the fetus, the severity of the disease, the localization of the pathological process, the rate of implementation, and manifestations of the pathology are an important type of pathogen, the path of penetration of microorganisms from mother to fetus to the immune response. Unfortunately, today the problem of preventing CBS is still far from being solved. However, knowledge of the pathogenesis, quality diagnostic methods, effective prevention, and treatment measures can significantly reduce the frequency of VUI and the severity of their consequences for the child.

Increase in frequency of disorders of women's reproductive function justifies a careful study of the underlying pathological processes. In recent years, increased attention in solving fertility problems is paid to endometrial pathology when chronic endometritis plays an important role. Current worksarefeeding an in-depth study of the etiology and pathogenesis of chronic endometritis. However, results of research pose new questions with an imaginary comprehensive study of this problem. Chronic endometritis is one of the causes of infertility and may play a role in certain complications of pregnancy and childbirth (30.3 % in patients with repeated failures of in vitro fertilization, 9.3 % with recurrent miscarriages, 9.8 % in infertility). Clinically, chronic endometritis is often asymptomatic or accompanied by nonspecific symptoms such as pelvic pain, dyspareunia, abnormal uterine bleeding, and discharges. Previously, scientists considered the uterine cavity as a sterile container. But a team of Spanish scientists sought to test for the presence of intrauterine microflora, which differs from the vaginal. As a result, the study of endometrial fluid and vaginal samples from the same patients revealed different bacterial compositions. Microflora in the intrauterine fluid was classified as Lactobacillus, and women with non-lactobacillary flora of the endometrium had a significantly lower frequency of implantation. At the initial stage of endometrial inflammation is an activation of neutrophils and macrophages, increased cytokines synthesis, extracellular matrix degradation by proteolytic enzymes. Disorders of microcirculation and sclerotic processes in the area of ​​injury lead to the ischemia and tissue hypoxia, which activates the processes of sclerosis and angiogenesis. Chronization of the process increases the expression of chemokines and adhesion molecules, that is lead to migration of B-lymphocytes from the bloodstream and their differentiation into plasma cells, increases the activity of matrix metalloproteinases, changes local expression of estrogen and progesterone receptors. Lack of a pronounced specific clinical picture of chronic endometritis, its later detection causes impaired reproductive function. Untimely diagnosis and treatment of chronic endometritis has significant consequences in terms of the possibility of implantation of a fertilized egg in the programs of assisted reproductive technologies.

The aim: To analyze Ukrainian and foreign literature data on the consequences of perinatal infection and the peculiarities of their manifestation. Materials and methods: Literature sources on the peculiarities of the course of infection that occur in the perinatal period and are a threat of congenital malformations or diseases in the newborn are collected. Conclusions: The analyzed data of the clinical picture and management of the early neonatal period fully reflect the coherence and timeliness of medical care for infants born with signs of perinatal infection. It should be noted that the tactics of such a newborn depend on the clinical manifestations, the general condition of the baby, and the duration of infection of the mother with a particular infection.