Meningeal carcinomatosis (MC) occurs in up to 5% of breast cancer patients. Few studies have evaluated prognostic markers in breast cancer patients with MC. Our aim was to describe the treatment of breast cancer patients with MC, and identify prognostic factors related to survival. Sixty breast cancer patients that had a diagnosis of MC between January 2003 and December 2009 were included. The median age was 46 years (range 27-76). Most patients had invasive ductal carcinoma (78.3%) and high histological/nuclear grade (61.7/53.3%). Estrogen and progesterone receptors were positive in 51.7 and 43.3% of patients, respectively, and 15% were HER-2-positive. Symptoms at presentation were headache, cranial nerve dysfunction, seizures, and intracranial hypertension signals. Diagnosis was made by CSF cytology in 66.7% of cases and by MRI in 71.7%. Intrathecal (IT) chemotherapy was used in 68.3% of patients, and 21.6% received a new systemic treatment (chemo- or hormone therapy). Median survival was 3.3 months (range 0.03-90.4). There was no survival difference according to age, nuclear grade, hormonal and HER-2 status, CSF features, sites of metastasis, systemic and IT chemotherapy, or radiotherapy. However, histological grade and performance status had a significant impact on survival in the multivariate analysis. Only four papers have addressed prognostic factors in breast cancer patients with MC in the last two decades. The results of those reports are discussed here. High histological grade and poor performance status seem to impact survival of breast cancer patients with MC. Prospective studies are necessary to clarify the role of IT and systemic treatment in the treatment of those patients.

ObjectiveTo evaluate knowledge on oral health and associated sociodemographic factors in pregnant women.MethodsA cross-sectional study with a sample of 195 pregnant women seen at the Primary Care Unit Paraisópolis I, in São Paulo (SP), Brazil. For statistical analysis, χ2 or Fisher's exact test and multiple logistic regression were used. A significance level of 5% was used in all analyses.ResultsSchooling level equal to or greater than 8 years and having one or two children were associated with an adequate knowledge about oral health.ConclusionOral health promotion strategies during prenatal care should take into account sociodemographic aspects.

OBJECTIVE:To develop a physical activity questionnaire aimed at Brazilian adolescents and to assess its validity and reproducibility. METHODS:A total of 94 adolescents (30 males and 64 females) aged 11-16 years were included in the study, which was conducted in 2004. The questionnaire comprised 17 questions on habitual physical activity in the last 12 months (15 questions on sports and physical exercise and two on transportation physical activity), and was standardized to yield final scores for weekly and yearly activity. As a reference, we used the multistage 20-meter shuttle run test, measuring variables maximum time in minutes, maximum speed, maximum oxygen uptake and maximum heart rate. For validity analysis, we used the Spearman coefficient and age-adjusted correlation. For reproducibility analysis, we repeated evaluations after 15 days and measured the intraclass correlation coefficient. RESULTS:For the weekly score, the highest correlations were obtained for maximum time for the entire sample (r=0.19), maximum speed for males (r=0.20), and both maximum oxygen uptake and maximum time for females (r=0.17). For the yearly score, the highest correlations were obtained for maximum time for the entire sample (r=0.30), maximum heart rate for males (r=0.22), and maximum time for females (r=0.23). In reproducibility analyses, correlations were 0.61 for weekly score and 0.68 for yearly score. CONCLUSIONS:The questionnaire was valid and reproducible. Its use is recommended for the evaluation of physical activity in epidemiological studies with adolescents.

OBJECTIVE:To develop a physical activity questionnaire aimed at Brazilian adolescents and to assess its validity and reproducibility. METHODS:A total of 94 adolescents (30 males and 64 females) aged 11-16 years were included in the study, which was conducted in 2004. The questionnaire comprised 17 questions on habitual physical activity in the last 12 months (15 questions on sports and physical exercise and two on transportation physical activity), and was standardized to yield final scores for weekly and yearly activity. As a reference, we used the multistage 20-meter shuttle run test, measuring variables maximum time in minutes, maximum speed, maximum oxygen uptake and maximum heart rate. For validity analysis, we used the Spearman coefficient and age-adjusted correlation. For reproducibility analysis, we repeated evaluations after 15 days and measured the intraclass correlation coefficient. RESULTS:For the weekly score, the highest correlations were obtained for maximum time for the entire sample (r=0.19), maximum speed for males (r=0.20), and both maximum oxygen uptake and maximum time for females (r=0.17). For the yearly score, the highest correlations were obtained for maximum time for the entire sample (r=0.30), maximum heart rate for males (r=0.22), and maximum time for females (r=0.23). In reproducibility analyses, correlations were 0.61 for weekly score and 0.68 for yearly score. CONCLUSIONS:The questionnaire was valid and reproducible. Its use is recommended for the evaluation of physical activity in epidemiological studies with adolescents.