Background: Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE surgery may lead to a sudden release of inflammatory mediators, which is associated with the severity of postoperative organ dysfunction. We investigated the impact of hemoadsorption during IE surgery on postoperative organ dysfunction. Methods: This multi-center, randomized, non-blinded, controlled trial assigned patients undergoing cardiac surgery for IE to hemoadsorption [integration of CytoSorb® to cardiopulmonary bypass (CPB)] or control. The Primary outcome (ΔSOFA) was defined as the difference between the mean total postoperative sequential organ failure assessment score (SOFA), calculated maximally to the 9th postoperative day, and the basal SOFA score. The analysis was by modified intention-to-treat. A predefined inter-group comparison was done using a linear mixed model for ΔSOFA including surgeon and baseline SOFA as fixed effect covariates and with the surgical center as random effect. The SOFA score assesses dysfunction in six organ systems, each scored from zero to four. Higher scores indicate worsening dysfunction. Secondary outcomes were 30-day mortality, durations of mechanical ventilation, vasopressor and renal replacement therapy. Cytokines were measured in the first 50 patients. Results: Between January 17, 2018 and January 31, 2020, A total of 288 patients were randomly assigned to hemoadsorption (n=142) or control (n=146). Four patients in the hemoadsorption and two in the control group were excluded as they did not undergo surgery. The primary outcome ΔSOFA did not differ between the hemoadsorption and the control group (1.79 ± 3.75 and 1.93 ± 3.53, respectively, 95% CI: −1.30 to 0.83, p=0.6766). Mortality at 30 days (21% hemoadsorption vs 22% control, p=0.782), the durations of mechanical ventilation, vasopressor and renal replacement therapy did not differ between groups. Levels of IL-1β and IL-18 at the end of CPB were significantly lower in the hemoadsorption than in the control group. Conclusions: This randomized trial failed to demonstrate a reduction in postoperative organ dysfunction through intraoperative hemoadsorption in patients undergoing cardiac surgery for IE. Although hemoadsorption reduced plasma cytokines at the end of CPB, there was no difference in any of the clinically relevant outcome points.

Indoor localization has recently and significantly attracted the interest of the research community mainly due to the fact that Global Navigation Satellite Systems (GNSSs) typically fail in indoor environments. In the last couple of decades, there have been several works reported in the literature that attempt to tackle the indoor localization problem. However, most of this work is focused solely on two-dimensional (2D) localization, while very few papers consider three dimensions (3D). There is also a noticeable lack of survey papers focusing on 3D indoor localization; hence, in this paper, we aim to carry out a survey and provide a detailed critical review of the current state of the art concerning 3D indoor localization including geometric approaches such as angle of arrival (AoA), time of arrival (ToA), time difference of arrival (TDoA), fingerprinting approaches based on Received Signal Strength (RSS), Channel State Information (CSI), Magnetic Field (MF) and Fine Time Measurement (FTM), as well as fusion-based and hybrid-positioning techniques. We provide a variety of technologies, with a focus on wireless technologies that may be utilized for 3D indoor localization such as WiFi, Bluetooth, UWB, mmWave, visible light and sound-based technologies. We critically analyze the advantages and disadvantages of each approach/technology in 3D localization.

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Miniature Vertical Take-Off and Landing (VTOL) vehicles have limited range of operations mainly due to their limited payload capacities and power availability. To increase this range, a modified unmanned ground vehicle (UGV) is used to transport the VTOL to its target area serving as an onsite take-off/landing and possibly refueling base. A gimbaled landing platform design is proposed and the necessary equations are derived to level the platform despite of the pose (roll, pitch, yaw) of the UGV. To increase UGV endurance, a solar array is used and solar tracking capabilities for performance maximization are examined. Simulations are carried out to check the validity of the design. The case of an ATRV-Jr as the UGV base and a Raptor 90SE as the VTOL is investigated, but the design is generic enough and suitable for other UGV/VTOL vehicles.

A Solid State device which can limit and interrupt a fault, apply power factor correction and voltage regulation under normal conditions is presented with an investigation of its efficiency. The losses of the switching semiconductors are investigated by employing the PSIM Thermal Module. This work closely investigates the phase shift between the current and voltage waveforms for a 50Hz system and switching frequency of 5kHz before modelling and calculating the IGBT losses. For DC/DC converters the associated currents and voltages are in phase. However, as this work shows for switched capacitor circuits there is a 90 o phase shift between current and voltage. Finally, calculated losses are compared to simulated losses as well as to other methodologies suggested in literature.