The condition known as hydropneumothorax occurs when fluid and air are both present in the pleural space. A bronchopleural fistula, an infection, a spontaneous pneumothorax, trauma, or rarely diffuse lung disease are a few conditions that might cause a hydropneumothorax. The most common radiographic finding in hydropneumothorax is an intrapleural air-fluid level. When hydropneumothorax is the major diagnosis, thoracentesis and chest radiographs offer a conclusive diagnosis. The current case report details an unusual cause of left-sided hydropneumothorax for a 78-year-old man who had a hydropneumothorax during his hospital stay, as well as how the problem was addressed with positive outcomes and patient satisfaction. Keywords: Hydropneumothorax, Pneumothorax, Hemothorax

Asthma is a diverse illness that can range in severity. Because it has a significant impact on patients' quality of life and because people with severe asthma have symptoms, exacerbations, and drug side effects. Although first disregarded, eosinophils have since been directly linked to characteristics of the continuous inflammatory process in asthma, especially in the severe form. We present of the case of a 50year old female patient who presented with complaints of cough, breathing difficult on exertion and history of fever, chest pain and tiredness. The chest x ray showed left lower zone haziness. Patient was successfully treated with IV antibiotics, IV Proton pump inhibitor, Nebulised bronchodilators, IV Steroids, Anti-Hypertensive therapy and all other supportive medications along with pulmonary rehabilitations. In view of uncontrolled Eosinophilic asthma patient was treated with monoclonal antibody. Patient improved symptomatically better. This case study describes how benralizumab treatment for a patient with uncontrolled severe eosinophilic asthma resulted in significant improvements in lung function, asthma control, steroid use, and quality of life. Keywords: Benralizumab, Severe eosinophilic asthma, Omalizumab, Monoclonal antibodies

Mills hemiplegic variant is a progressive motor neuron disease characterized by spastic ascending or descending hemiparesis or hemiplegia with no sensory involvement. We presented a 53years old male patient with a history of present complaints was difficulty on walking, and difficulty in speech then he developed left lower limb weakness followed by left upper limb weakness for the last 6 months. Electromyography showed a neurogenic pattern with denervation with reinnervation. Then, he successfully accomplished his treatment. The biggest challenge in making a diagnosis is ruling out other conditions that may have symptoms similar to this disease entity. Keywords: Mills hemiplegic, Electromyography, Motor neuron disease