The work was devoted to the study of the effectiveness of the application of multi-component coatings, TiN–Al/TiN, TiN–AlTiN/SiN, and CrTiN–AlTiN–AlTiCrN/SiN, obtained by cathodic arc deposition to increase the wear resistance of 6WH10F carbide end mills in trochoidal milling of titanium alloy. The surface morphology of the tool with coatings was studied using scanning electron microscopy, and surface roughness texture was estimated. Microhardness and elastic modulus of the coated carbide tool surface layer were determined by nanoindentation. The process of sticking titanium to the working surface of the tool and quantitative evaluation of end mill wear with multi-component coatings at the trochoidal strategy of milling titanium alloy was studied. The CrTiN–AlTiN–AlTiCrN/SiN coating showed the maximum value of the plasticity index at the level of 0.12. The maximum effect of reducing the wear rate was achieved when using a tool with a CrTiN –AlTiN–AlTiCrN/SiN coating when the operating time to failure of end mills was increased by 4.6 times compared to samples without coating, by 1.4 times compared with TiN–Al/TiN coating and 1.15 times compared with TiN–AlTiN/SiN coating.