Group of 152 patients (investigated before autologous transplantation) and 35 healthy donors for allogeneic transplantation was examined for the risk of infection transmission that can be associated with the infusion of cryopreserved peripheral blood progenitor cells to the patient and/or cross-contamination of stored grafts. No laboratory signs of active infection were found in 22 donors (63 %) and in 91 patients (60%). The most common was active infection by herpes viruses--50 cases in patients, 21 cases in donors; hepatitis B was found in only two cases. The rate of clinically unsuspected (but dangerous) infections in donors and patients thus remains relatively high in spite of the fact that the system of donor search and the whole transplantation procedure have improved in the last years. The system of safety assurance is extremely important and the whole palette of preventive tests according to EBMT (European Blood and Marrow Transplantation Group) and ISHAGE (International Society for Hemotherapy and Graft Engineering) is fully justified.

In a group of 71 patients and 22 donors the danger of infection transmission by infusion of cryopreserved peripheral blood progenitor cells to the patient and/or cross contamination of stored grafts was evaluated. No laboratory signs of active infection were found in 15 donors (13 related, 2 unrelated; 68%) and in 55 patients (77%). Active infection by herpesviruses was the most common (in 13 patients and 7 donors), hepatitis B being found in only one case. The cytomegalovirus IgG test was the most common marker of previous infection; it was found in 14 donors and 55 patients. The rate of clinically unsuspected infections in donors and patients including cases requiring immediate treatment among the patients group is relatively high and fully justifies the practice of prophylactic serological testing in the whole range of tests according to the European Blood and Marrow Transplantation Group and International Society for Hematotherapy and Graft Engineering in both autologous and allogeneic transplantations of hematopoietic stem cells.

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The disease is detected in Central Yakutia and deserves the closest attention from practicing veterinarians. In village dogs infected with and suffered from dirofilariasis, the main pathomorphological changes were localized in the heart and were represented by atrophic, dystrophic and necrobiotic processes. In addition, the products of the nematode metabolism led to the appearance of circulatory disorders. First of all, the researchers paid attention to the study of blood smears, which showed the microfilariae in the smears. The authors also examined guard dogs that died from this disease, and an incomplete examination of organs and tissues when dissecting the heart, lungs and parenchymatous organs, showed sexually mature Dirofilaria in the heart of the dissected animals. Subsequently, methods for diagnosing dirofilariasis were applied using the method of peripheral blood examination, where live microfilariae larvae were found in sick dogs. As the authors of the article note, cardiac dirofilariasis subsequently had a destructive effect on red blood cells, erythrocytes, and was observed in the development of hemoglobinemia, and hemoglobinuria, and in some cases leads to liver and kidney failure. In the respiratory system, there were also typical clinical signs of chronic dry cough, difficult breathing and shortness of breath, and foci of pulmonary rales detected. During the disease, pulmonary thromboembolism was developed in the animals, which characterized by the occurrence of fever and the release of sputum with blood. In the treatment of canine dirofilariasis, the authors observed a fatal outcome in two cases, and made dissections to study the organs and tissues affected by nematodes.