1-[6-(1H-Pyrrolo[2,3-b]pyridin-1-yl)pyridin-2-yl]-1H-pyrrolo[2,3-b]pyridin-7-ium tetrachloridoferrate(III), (C(19)H(14)N(5))[FeCl(4)], (II), and [2,6-bis(1H-pyrrolo[2,3-b]pyridin-1-yl-kappaN(7))pyridine-kappaN]bis(nitrato-kappaO)copper(II), [Cu(NO(3))(2)(C(19)H(13)N(5))], (III), were prepared by self-assembly from FeCl(3).6H(2)O or Cu(NO(3))(2).3H(2)O and 2,6-bis(1H-pyrrolo[2,3-b]pyridin-1-yl)pyridine [commonly called 2,6-bis(azaindole)pyridine, bap], C(19)H(13)N(5), (I). Compound (I) crystallizes with Z' = 2 in the P\overline{1} space group, with both independent molecules adopting a trans-trans conformation. Compound (II) is a salt complex with weak C-H...Cl interactions giving rise to a zigzag network with pi-stacking down the a axis. Complex (III) lies across a twofold rotation axis in the C2/c space group. The Cu(II) center in (III) has an N(3)O(2) trigonal-bipyramidal environment. The nitrate ligand coordinates in a monodentate fashion, while the bap ligand adopts a twisted tridentate binding mode. C-H...O interactions give rise to a ribbon motif.

The protein folding reaction is one of the most important chemical reactions in the human body. Yet, despite its importance, it is sometimes omitted from undergraduate courses due to the challenging nature of some of the underlying concepts. To help make key concepts of the protein folding reaction accessible to our undergraduate students, we implemented three, simplified 2D lattice models of various amino acid chains, and we used these models to generate sound-enhanced animations that allow students to see and hear the dynamics of protein folding in action. In spring of 2021, we used these videos in remote learning biophysics and music courses to introduce four key concepts of the folding reaction: solvation and hydrophobicity; energy and conformational entropy; funneled energy landscape; and frustration and traps. Our lattice model animations and sonifications helped provide insight into protein folding dynamics for undergraduate and graduate biophysical chemistry students, undergraduate musicians, and even authors who are experts in this field. We plan to incorporate these and additional animations, along with enhancements to the 2D lattice models, in our future courses.

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Electrochemical reduction of the dinitrogen-derived dicyanovinyl hydratido(2-) complex] -[ d p pe = bis (d i p hen y I p hos p h i no) et h a ne] i n tetra h y d rof u ra n yields 5-amino-4-cyanopyrazole in up to 50% yield; when carried out under N2, the metal-containing