No abstract

Thin superconducting films are predicted to be highly reflective mirrors for gravitational waves at microwave frequencies. The quantum mechanical non-localizability of the negatively charged Cooper pairs, which is protected from the localizing effect of decoherence by an energy gap, causes the pairs to undergo non-picturable, non-geodesic motion in the presence of a gravitational wave. This non-geodesic motion, which is accelerated motion through space, leads to the existence of mass and charge supercurrents inside the superconducting film. On the other hand, the decoherence-induced localizability of the positively charged ions in the lattice causes them to undergo picturable, geodesic motion as they are carried along with space in the presence of the same gravitational wave. The resulting separation of charges leads to a virtual plasma excitation within the film that enormously enhances its interaction with the wave, relative to that of a neutral superfluid or any normal matter. The existence of strong mass supercurrents within a superconducting film in the presence of a gravitational wave, dubbed the "HeisenbergCoulomb effect," implies the specular reflection of a gravitational microwave from a film whose thickness is much less than the London penetration depth of the material, in close analogy with the electromagnetic case. The argument is developed by allowing classical gravitational fields, which obey Maxwell-like equations, to interact with quantum matter, which is described using the BCS and Ginzburg-Landau theories of superconductivity, as well as a collisionless plasma model. Several possible experimental tests of these ideas, including mesoscopic ones, are presented alongside comments on the broader theoretical implications of the central hypothesis.

Motivation Antimicrobial peptides (AMPs) are promising alternative antimicrobial agents. Currently, however, portable, user-friendly, and efficient methods for predicting AMP sequences from genome-scale data are not readily available. Here we present amPEPpy, an open-source, multi-threaded command-line application for predicting AMP sequences using a random forest classifier. Availability amPEPpy is implemented in Python 3 and is freely available through GitHub (https://github.com/tlawrence3/amPEPpy). Contact lawrencetj@ornl.gov or labbejj@ornl.gov Supplementary information Supplementary data are available at Bioinformatics online.

A thought experiment is proposed to demonstrate the existence of a gravitational, vector AharonovBohm effect. We begin the analysis starting from four Maxwell-like equations for weak gravitational fields interacting with slowly moving matter. A connection is made between the gravitational, vector Aharonov-Bohm effect and the principle of local gauge invariance for nonrelativistic quantum matter interacting with weak gravitational fields. The compensating vector fields that are necessitated by this local gauge principle are shown to be incorporated by the DeWitt minimal coupling rule. The nonrelativistic Hamiltonian for weak, time-independent fields interacting with quantum matter is then extended to time-dependent fields, and applied to problem of the interaction of radiation with macroscopically coherent quantum systems, including the problem of gravitational radiation interacting with superconductors. But first we examine the interaction of EM radiation with superconductors in a parametric oscillator consisting of a superconducting wire placed at the center of a high Q superconducting cavity driven by pump microwaves. Some room-temperature data will be presented demonstrating the splitting of a single microwave cavity resonance into a spectral doublet due to the insertion of a central wire. This would represent an unseparated kind of parametric oscillator, in which the signal and idler waves would occupy the same volume of space. We then propose a separated parametric oscillator experiment, in which the signal and idler waves are generated in two disjoint regions of space, which are separated from each other by means of an impermeable superconducting membrane. We find that the threshold for parametric oscillation for EM microwave generation is much lower for the separated configuration than the unseparated one, which then leads to an observable dynamical Casimir effect. We speculate that a separated parametric oscillator for generating coherent GR microwaves could also be built.