The ability of p53 to function as a transcription factor is instrumental in facilitating the response to cellular stress, and p300/CBP proteins, which act as coactivators for diverse transcription factors, participate in regulating p53 activity. We report a novel cofactor for p300 that facilitates the p53 response by augmenting p53-dependent transcription and apoptosis. JMY and p300 associate in physiological conditions, and, during the cellular stress response, the p300/JMY complex is recruited to activated p53. The bax gene is efficiently activated by JMY, and protein isoforms that arise through alternative splicing alter the functional outcome of the p53 response. The results provide compelling evidence that the p300/JMY coactivator complex plays a central role in facilitating the p53 response.

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We introduce a method for identifying, analyzing, and visualizing submarkets in product categories. We give an overview of the market structure and competitive submarket literature and then describe a classic model for testing competitive submarkets along with associated extensions. In the era of big data and with the increasing availability of large-scale consumer purchase data, there is a need for techniques that can interpret these data and use them to help make managerial decisions. We introduce a statistical likelihood based technique for both identifying and testing market structure. We run a series of experiments on generated data and show that our method is better at identifying market structure from brand substitution data than a range of methods described in the marketing literature. We introduce tools for holdout validation, complexity control, and testing managerial hypotheses. We describe a method for visualization of submarket solutions, and we give several traditional consumer product examples and in addition give an example to show how market structure can be analyzed from online review data. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mksc.2015.0958 .

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