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The awareness of simulation technologies within the UK is relatively small when compared with the USA. Subsequently several large US companies have been able to overcome the difficulties in adopting new technology into their business and introduce simulation. This paper investigates the problems encountered and the practices helping to successfully implement simulation into a company environment. Details of a major survey conducted to determine the approaches taken by large automotive and aer0spac.e companies within these two countries are outlined. The survey highlighted differences in the development of simulation within twelve large companies, the extent of the difference and the reasons why these differences exist.

The fluoroquinolones have an established role in treatment of infection with aerobic gram negative rods. The increased importance of gram positive nosocomial infection and of acquired fluoroquinolone resistance has stimulated a search for new compounds with enhanced potency and spectrum. CP-99,219 is a novel compound in this class with enhanced activity against gram positive organisms. We have studied the activity of CP-99,219 relative to ciprofloxacin, fleroxacin, ofloxacin, and sparfloxacin using test panels of organisms with a high proportion of ciprofloxacin resistance. CP-99,219 is more potent than any of the other four compounds against both gram positive and gram negative bacteria. The activity of CP-99,219 against many bacteria resistant to the established agents, warrants further in vitro and clinical studies.