NMP, NaOAc, TBAB

We herein report a highly active catalyst system using for the first time a thiadiazolidine 1-oxide as a ligand for palladium in the MizorokiHeck reaction. Excellent yields of stilbenes derived from aryl iodides and bromides have been achieved using as little as 0.00002 mol% catalyst. The ligand/ palladium system can be stored as a stock solution open to air at room temperature with no observable loss of activity for a period of several weeks/ months.

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Reactions carried out with substoicheiometric quantities of organic molecules as catalysts have received much attention over the past decade. This review highlights progress in 2009 towards highly enantioselective organocatalytic systems and the natural product/biologically active compounds that can be prepared using these types of processes.