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Motivation The 3D structure of chromatin in the nucleus is important for gene expression and regulation.  Chromosome conformation capture techniques, such as Hi-C, generate large amounts of data showing interaction points on the genome but these are hard to interpret using standard tools. Results We have developed CSynth, an interactive 3D genome browser and real-time chromatin restraint-based modeller to visualise models of any chromosome conformation capture (3C) data. Unlike other modelling systems CSynth allows dynamic interaction with the modelling parameters to allow experimentation and effects on the model. It also allows comparison of models generated from data in different tissues / cell states and the results of third-party 3D modelling outputs. In addition, we include an option to view and manipulate these complicated structures using Virtual Reality (VR) so scientists can immerse themselves in the models for further understanding. This VR component has also proven to be a valuable teaching and public engagement tool. Availability CSynth is web based and available to use at https://csynth.org. Supplementary information Supplementary data are available at Bioinformatics online.

The modular symmetries of string loop threshold corrections for gauge coupling constants are studied in the presence of discrete Wilson lines for all examples of abelian orbifolds, where the point group is realised by the action of Coxeter elements or generalised Coxeter elements on the root lattices of the Lie groups.

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