Huntington disease is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this paper, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through Large Deformation Diffeomorphic Metric Mapping of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. Based on the relation to cortico-basal-ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

By examining Hispanic students both currently and formerly enrolled at a private, Hispanic-serving Institution located in the Southwestern region of the United States, this study attempts to understand the factors that lead to Hispanic undergraduate persistence to graduation. Adapting Bronfenbrenner’s theoretical approach, this study explores three dimensions that are critical to understanding Hispanic undergraduate persistence to graduation: (a) the role of the student context (b) the role of the university context in the student’s decision to persist; and (c) the interaction between the two contexts.

A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good potency against RXRalpha (K(i) = 6 nM) but was also found to be greater than 167-fold selective vs RARalpha (K(i) > 1000 nM). This compound profiled out as a full agonist in a cell-based transient transfection assay (EC(50) = 3 nM). The two antipodes were separated via chiral chromatography, and 46b was found to be 40-fold more potent than 46a. Interestingly, cocrystallization of 46a,b with the RXRalpha protein generated a liganded structure whereby the (S)-antipode was found in the binding pocket. Given orally in db/db mice or ZDF rats, 46a,b showed a significant glucose-lowering effect and an increase in liver mass. Triglycerides decreased significantly in db/db mice but increased in the ZDF rats. A dose-dependent decrease of nonesterified free fatty acids was seen in ZDF rats but not in db/db mice. These differences indicate a species specific effect of RXR agonists on lipid metabolism.

This study examined Hispanic undergraduate students' campus engagement at a private Hispanic Serving Institution. Through an analysis of survey responses of 84 students, a new measurement of ethnic loyalty is utilized. This study found that students who are more ethnically loyal are more likely to partake in campus resources than other students. In exploring Hispanic students' background in a novel way, this study contributed to efforts to promote integration and Hispanic student success. Resumen Este estudio examinó la conexión universitaria que estudiantes de pregrado tienen en una universidad privada que sirve a hispanos. Utilizando una medida nueva de lealtad étnica se analizaron las respuestas de 84 estudiantes. Se encontró que los estudiantes más leales étnicamente tienen más probabilidades de utilizar los recursos universitarios. Al explorar los antecedentes de los estudiantes hispanos en forma nueva, este estudio contribuyó a los esfuerzos promotores de integración y al éxito estudiantil hispano.