of 1.84 years (95% confidence interval, 1.24-2.43 years) compared with 7.13 years (95% confidence interval, 0.84-13.42) for patients not taking narcotic medications (Fig) . Multivariate logistic regression showed that narcotic use before surgery (odds ratio [OR], 3.73; P ¼ .029), prior vascular interventions (OR, 4.06; P ¼ .043), and external iliac artery stenosis/occlusion (OR, 3.25; P ¼ .02) remained as significant predictors for amputation (Table ).Conclusions: Narcotic use and external iliac stenosis were associated with higher amputation rates after infrainguinal bypass. Inflow lesions should be addressed concomitantly or before infrainguinal revascularization. For patients taking narcotics preoperatively, a decreased chance of limb salvage should be considered by patients and clinicians as a part of the decision-making process.