Endogenously expressed CReg on PASMC poorly protect these cells to human C. Human C can induce proliferation of PASMC. In order to prevent accelerated atherosclerosis in porcine xenografts, increased levels of CReg not only have to be obtained on the endothelial cells but also on the smooth muscle cells.

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Sequential testing has been employed in clinical assessments to support student progression decisions by strategically targeting assessment resources towards borderline students. In this context resampling techniques have been utilised in the attempt to determine the appropriate blueprint number of stations to include in the screening phase of a sequential exam. However, statistical overfitting undermines the generalizability of examination psychometric properties and the uneven distribution (imbalance) of borderline vs. non-borderline students may cause resampling methods to produce biased results. Both phenomena may mislead educational practitioners when redesigning sequential assessments. We demonstrate how to mitigate against the problems of overfitting and imbalanced cohorts whilst finding the optimal 9 screening stations out of an 18-station OSCE. To prevent overfitting our statistical model was developed on one set of data (train and test) and then validated on a different dataset (validation) with imbalance accounted for by operating a stratified sampling scheme. The outcomes demonstrate the importance of validation: in the development phase, the accuracy was initially 91% (train) but the actual predictive accuracy when mitigating against overfitting and imbalance was 86% (test). Similarly, when we validated the model on completely new data-with a comparable assessment-the predictive accuracy was 83% (validation).

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