T o help celebrate the 115th anniversary of this publication, I spent some time researching the history of the Southern Medical Journal (SMJ). I found that no comprehensive and definitive history exists, but I did find some reliable information regarding the history of the SMJ from the early 20th century to the present.The beginnings of the SMJ are not precisely clear.

C oronavirus disease 2019 (COVID-19) vaccination rates remain insufficient to achieve worldwide herd immunity with respect to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Two issues are primarily responsible for this. Many countries want to achieve herd immunity through mass vaccination against SARS-CoV-2 virus but do not have the resources to do so. These countries may have a great supply of willing arms but have an insufficient supply of vaccine doses and/or other resources necessary to distribute and administer the needed vaccine doses to achieve herd immunity. Ironically, and sadly, many resource-rich countries, particularly the United States, have abundant vaccination supplies but limited numbers of individuals willing to receive vaccinations.Perhaps it is time to stop waiting for more people in resourcerich countries to accept COVID-19 vaccinations and focus more efforts on the large population that resides in resource-limited countries that do not have access to COVID-19 vaccines. Perhaps such an approach will achieve much greater marginal value for COVID-19 vaccine doses by increasing vaccination rates more quickly for much more of the world's population than by waiting indefinitely for vaccine nonaccepters to change their behaviors. Achieving a vaccination rate of >80% of people living in a community or country has been proposed to be the necessary vaccination prevalence threshold to achieve herd immunity. Thus far,

Numerous oral and parenteral anticoagulant drugs are now available for clinical use. Understanding the precise pharmacologic properties of each anticoagulant is imperative for those practitioners who prescribe these drugs, including knowing the current recommendations for reversing the anticoagulant effect of each anticoagulant. This review provides a brief description of the various anticoagulants used today and also discusses the pharmacologic properties of those drugs used to reverse the anticoagulant action of specific anticoagulants.