In vitro and in vivo studies were conducted to evaluate the efficacy of organozeolite (Min-a-Zel Plus®) to alleviate the toxic effects of zearalenone (ZEN) in lambs. Min-a-Zel Plus® was able to bind >90% of ZEN in vitro at pH 3, 7 and 9. For in vivo studies, sixty four lambs were divided in to four groups which included: I - control group - basal diet containing neither Min-a-Zel Plus® nor zearalenone; II - basal diet supplemented with 8.3 mg ZEN/kg diet; III - basal diet supplemented with 8.3 mg ZEN/kg and 0.2% Min-a-Zel Plus®; IV - basal diet supplemented with 8.3 mg ZEN/kg and 0.5% Min-a-Zel Plus®. The Min-a-Zel Plus® supplement dramatically reduced the content of ZEN in liver, kidneys and muscles. The lower amount (0.2%) reduced the content of ZEN in all samples, but ZEN was still present in the organs. Addition of 0.5% Min-a-Zel Plus® eliminated ZEN from all organs, totally. These results indicate that Min-a-Zel Plus® is effective in preventing the toxic effects of ZEN, which may be present in lamb rations