Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

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Objective: To evaluate the visual outcomes of Contoura Vision with automatic eye tracking system in eyes with myopia and myopic astigmatism. Methods: In this prospective study, 40 consecutive patients (80 eyes) with moderate myopia and irregular astigmatism were included from January to August 2018 at Liuzhou Worker’s Hospital. Subjects were randomly divided into an experimental group (40 eyes) that underwent Contoura Vision FS-LASIK and a control group (40 eyes) that underwent wavefront-optimized FS-LASIK. Target refractions of all subjects were plano. Visual outcomes and astigmatic vector analysis were evaluated and compared between preoperatively and 3 months post-operatively. Results: The preoperative spherical and cylindrical refractive errors were similar in both groups (P>0.05). At 3 months postoperatively, cumulative uncorrected distance visual acuity (UDVA) was 20/16, 20/20, or 20/25 in 30 %, 95%, 100 % of patients in the experimental group, respectively. The experimental group was better than the control group in predictability of astigmatism correction at 3 months after operation. In the experimental group, 80% of eyes had deviation of astigmatic axis within 15° and 35% of eyes had deviation of astigmatic axis within 5°, both were better than those in the control group. The number of eyes with residual astigmatism within 0.5D were higher in the experimental group (60%, 24 eyes) than the control group (50%, 20 eyes). Compared with the preoperative, C7 significantly reduced to 0.056±0.030 in the experimental group at 3 months after the procedure (P<0.05), and were significantly lower than those in the control group (P<0.05). Conclusion: Contoura Vision with automatic eye tracking system was safe and effective for the correction of myopia and myopic astigmatism. Key words: vector analysis; irregular astigmatism; Contoura Vision

Objective: To evaluate the visual outcomes of Contoura Vision with automatic eye tracking system in eyes with myopia and myopic astigmatism. Methods: In this prospective study, 40 consecutive patients (80 eyes) with moderate myopia and irregular astigmatism were included from January to August 2018 at Liuzhou Worker’s Hospital. Subjects were randomly divided into an experimental group (40 eyes) that underwent Contoura Vision FS-LASIK and a control group (40 eyes) that underwent wavefront-optimized FS-LASIK. Target refractions of all subjects were plano. Visual outcomes and astigmatic vector analysis were evaluated and compared between preoperatively and 3 months post-operatively. Results: The preoperative spherical and cylindrical refractive errors were similar in both groups (P>0.05). At 3 months postoperatively, cumulative uncorrected distance visual acuity (UDVA) was 20/16, 20/20, or 20/25 in 30 %, 95%, 100 % of patients in the experimental group, respectively. The experimental group was better than the control group in predictability of astigmatism correction at 3 months after operation. In the experimental group, 80% of eyes had deviation of astigmatic axis within 15° and 35% of eyes had deviation of astigmatic axis within 5°, both were better than those in the control group. The number of eyes with residual astigmatism within 0.5D were higher in the experimental group (60%, 24 eyes) than the control group (50%, 20 eyes). Compared with the preoperative, C7 significantly reduced to 0.056±0.030 in the experimental group at 3 months after the procedure (P<0.05), and were significantly lower than those in the control group (P<0.05). Conclusion: Contoura Vision with automatic eye tracking system was safe and effective for the correction of myopia and myopic astigmatism. Key words: vector analysis; irregular astigmatism; Contoura Vision