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Sustainability is the ability to nurture or support a process for an extended period without compromising the needs of the future generation. Sustainable chemistry is a term that refers to the creation of chemical products and processes that decreases or remove the use and production of hazardous substances. Even though sustainable and green technologies have evolved in other scientific fields, their use in the pharmaceutical industry is still initial stage. Therefore, we need to work in green chemistry to ensure its growth in the pharmaceutical industry. Thus, the current review aimed to highlight the need for green chemistry or sustainable chemistry and its principles and its application in the pharmaceutical industry to practice environment-friendly production of pharmaceutical products and reduce or stop the production of harmful intermediates and products during the synthesis process.

Background: Despite its widespread use in traditional medicine, availability of a report on the toxicity of stem bark extract of (Asan) is lacking largely. So the present study aims to provide an account of the acute Terminalia tomentosa toxic potential of the ethanolic extract of the dried stem bark of in accordance to OECD TG 425. Terminalia tomentosa Materials and Methods: Female mice were randomly assigned to either test or control groups (n = 5). The test animals received a single dose of 2000 mg/kg b.w.bark extract while the control ones received vehicle of equal T. tomentosa volume. Both the groups were kept under observation for a period of fourteen days for signs of mortality and morbidity. Blood samples were collected periodically through the observation period for assessing hematological and biochemical parameters. Animals were sacrificed at the end of the observation period and vital organs were collected for histopathological analysis.The data presented is indicative of the conclusion that LD of the extract is beyond Results: 50 2000 mg/kg and hence the extract under investigation can be considered practically non-toxic. The vital parameters fairly remained constant across the groups with no significant alterations observed in the animals of either groups with respect to ALT, total protein, globulin etc. though AST was slightly raised in the test groups with a dip in ALP. Hematological and biochemical parameters however didn't show significant variation between the groups. Conclusion: Results suggest that LD of the extract is greater than 2000 mg/kg and the putative role of the same in 50 hepatoprotection is hinted by the elevation of AST in the test group.

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