Emergency situations typically lead to a plethora of public attention on social media platforms like ‘Twitter’. Twitter provides a unique opportunity for public health researchers to analyze untampered information shared during a disease outbreak. Considering the ongoing public health emergency, we conducted a study investigating the public reaction to COVID-19 pandemic around the world using in-depth thematic analysis of Twitter data. A dataset of 212846 tweets was retrieved over a period of seven days (from April 13, 2020, to April 19, 2020) via Twitter Application Programme Interface (API). The following five keywords were used to collect the tweets: “coronavirus”, “covid-19”, “corona”, “covid”, “covid19”. After data filtering and cleaning 6348 tweets were randomly selected for in-depth thematic analysis. Thematic analysis was done manually using a two-level coding guide. A total of six main themes emerged from the analysis: ‘sentiments and feelings’, ‘Information’, ‘General Discussion’, ‘Politics’, ‘Food’, and ‘Sarcasm or humor’. The aforementioned themes were divided into 26 sub-themes. The results of the thematic analysis show that 30.1% of the tweets were regarding ‘sentiments and feelings’, 15.6% were regarding ‘politics’, and 6.5% were related to ‘sarcasm or humor’. The present study is the first study that has analyzed the public response to COVID-19 on Twitter. The study demonstrates that social media platforms (like Twitter) can be used to conduct infodemiological studies related to public health emergencies like the COVID-19 pandemic. We believe that the results of this study will be of potential interest to policymakers, health authorities, stakeholders, and public health and social science researchers. KEYWORDS:COVID-19, Twitter, Social Media, Coronavirus, Lockdown, Pandemic
The overexpression of Epidermal Growth Factor Receptor (EGFR) and dysregulation of its downstream effector pathways are important molecular hallmarks of oral cancers. Present study investigates the chemopreventive potential of polymeric black tea polyphenols (PBPs)/thearubigins (TRs) in the hamster model of oral carcinogenesis as well as determine the effect of PBPs on EGFR and the molecular players in the EGFR pathway. In dose-dependent manner, pre and concurrent treatment with PBPs (1.5%, 5%, 10%) decreased the number and volume of macroscopic tumors as well as the number and area of microscopic lesions. Interestingly, at 10% dose of PBPs, no macroscopic or microscopic tumors were observed. We observed PBPs mediated dose-dependent decrease in oxidative DNA damage (8OHdG); inflammation (COX-2); proliferation (PCNA, Cyclin D1); expression of EGFR, and its downstream signaling kinases (pAkt, Akt, and mTOR); hypoxia (HIF1α) and angiogenesis (VEGF). There was also a PBPs mediated dose-dependent increase in apoptosis (Bax). Thus, our data clearly indicate that the observed chemopreventive potential of PBPs was due to modulation in the EGFR pathway associated with cell proliferation, hypoxia, and angiogenesis. Taken together, our results demonstrate preclinical chemopreventive efficacy of PBPs and give an insight into its mechanistic role in the chemoprevention of experimental oral cancer.
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