The present study is focused on the flood inundation in Brahmaputra Basin, which is one of the most recurrent and destructive natural disasters of the region. The flood inundation was assessed using C-Band Sentinel 1A synthetic aperture radar (SAR) during 2015–2020 with precipitation patterns, runoff discharge, and their impacts on land cover in the basin. The study exhibited a very high precipitation during monsoon in the upper catchment resulting in severe flood inundation in downslopes of Brahmaputra Basin. A very high (900–2000 mm) to extremely high (>2000 mm) monthly cumulative precipitation in the south and south-eastern parts of basin led to high discharge (16,000 to 18,000 m3s-1) during July-August months. The river discharge increases with cumulative effects of precipitation and melting of snow cover during late summer and monsoon season, and induced flood inundation in lower parts of basin. This flood has largely affected agricultural land (>77% of total basin), forests (~3%), and settlement (426 to 1758 km2) affecting large wildlife and livelihood during 2015–2020. The study highlights the regions affected with recurrent flood and necessitates adopting an integrated, multi-hazard, multi-stakeholder approach with an emphasis on self-reliance of the community for sustenance with local resources and practices.