Tandem C–N bond formation for the oxidative annulation of indolines with aziridines is accomplished employing the combination of DDQ and NaOCl at ambient conditions. Optically active aziridine can be coupled with high enantiomeric purity (>99% ee). The substrate scope, stereocontrol with the enantioenriched substrate, and scale-up are the important practical advantages.

Co-catalyzed stereospecific C−N and C−O bond formation of oxiranes with diaziridines has been accomplished to furnish tetrahydro-[1,3,4]-oxadiazines at room temperature. Optically active oxiranes can be coupled with high optical purities (>96% ee). Stereoselectivity, functional group tolerance, mechanistic studies using DFT, and natural product modification are the important practical features.

The efficient Bi-catalyzed 1,2-reactivity of spirocyclopropyl oxindoles has been disclosed with dithianediols as the sulfur surrogate to furnish spiroheterocycles at moderate temperature. The procedure provides a potential approach for the construction of spirotetrahydrothiophene scaffolds with functional group diversity. The catalytic 1,2-reactivity of cyclopropanes, mechanistic studies using density functional theory studies, diastereoselectivity, and additive-free mild conditions are the important practical features.

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Stereospecific cascade CÀ N and CÀ O bonds formation of oxiranes with N-propargylamines is achieved to furnish functionalized dihydrooxazines by employing Zn/Ag relay catalysis.The reaction shows great functional group tolerance, and is practically scalable.