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Late wound complications, such as dehiscence or infection, are rare following the retrosigmoid approach, especially when the cranial opening is small. Here, we report two cases of late wound complications after lateral suboccipital craniectomy and cranioplasty with polymethyl methacrylate. Sudden neck rotation was the cause of complications in both cases, and seroma formation, wound dehiscence, and infection developed subsequently 4 and 19 years after surgeries, respectively.