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Background: Adverse drug reactions (ADRs) are recognised causes of increased mortality, morbidity, and high healthcare costs. The contribution of healthcare students to ADR databases is essential and has enabled continued drug detection to such an extent that it has led to identifying unsuspected and rare ADR signals.    Objectives: The study aims to evaluate healthcare students’ knowledge, attitude, and practice (KAP) toward ADR reporting.    Methods: This descriptive, cross-sectional study was conducted among 265 healthcare students of Namakkal district, Tamil Nadu, from various departments. A three-section questionnaire was developed in English and distributed online from July to October 2020. Each participant received a score for each KAP section. Results: Of the 265 healthcare students included in the study, 56.98% were female. The majority were pharmacy students 132 (49.81%), followed by medical 74 (27.92%) and nursing 59 (22.26%) students. There was a significant difference in ADR reporting among healthcare students. KAP of ADR reporting was higher among pharmacy students (88.68%) compared to the medical (19.25%) and nursing students (29.63%), with a p-value of 0.05. Conclusion: This study showed that pharmacy students had more awareness of ADR reporting than other healthcare students due to pharmacovigilance courses in their curriculum and adequate training during clerkships and internships. Hence, it is necessary to include pharmacovigilance and ADR reporting in other healthcare curriculum to reduce ADR underreporting in the future. Periodic educational interventions can improve these parameters of pharmacovigilance.

Aim:To evaluate the shear bond strength of orthodontic lingual bracket systems bonded to extracted premolar teeth (Reliance self-etching primer, Clearfil Protect Bond) and self-etching primer (Clearfil SE Bond) Materials and methods:A total of 160 extracted human first premolars were selected and divided into four groups of 10 for each bracket system to be used with four different primers. Each sample was then embedded in an acrylic block, till the coronal portion. Instron testing machine model LR LOYD 50 K was used for testing the shear bond strength. Results:The results obtained, suggested that all the primers had clinically acceptable shear bond strength with all the bracket system considered in the study. However, there were statistically significant differences in the shear bond strength in intergroup comparisons. Conclusion:The Reliance Self-Etching primer showed the highest bond strength with Alias lingual bracket system by Ormco, followed by clearfil protect bond, clearfil SE bond, and transbond, with the Alias lingual bracket system in the same order. Clinical significance:This study was initiated to understand the shear bond strength of self-etching primer and its efficacy over the conventional primer, which will be of use to the clinician while selecting the primer for bonding of the bracket systems and overcome debonding of brackets encountered during the treatment progress.

Guillain-Barré syndrome (GBS) is an immune-mediated disease that affects peripheral nerves and can lead to life-threatening consequences. It affects around 10000 people per year worldwide. Since the outbreak of acute respiratory syndrome coronavirus-2 (sar-cov-2) the incidence of GBS has been increased with a fatality rate of 4-7%. The exact association between the Sar-cov-2 and GBS is still unknown. GBS commonly presents after viral infections such as influenza virus, campylobacter jejuni, and zika virus. Clinical recognition of SC2-GBS is required in order to administer appropriate treatment on time and enhance the overall output of the infection. In most of the conditions patient was treated with intravenous immunoglobulins and outcome was seen within eight weeks of treatment. less outcome was seen in older age in line with previous findings for both GBS and COVID-19. Studies should be conducted to compare patients associated with GBS to those with concurrent non-COVID-19 GBS to see if the incidence of GBS is higher in those with COVID-19. Keywords: Guillian-Barre syndrome, COVID-19, SAR-COV2