Introduction: Diabetes is a very prevalent problem in Pakistan. Depression along with diabetes affects not only quality of life but compliance and management of patient. Various studies have found high prevalence of depression among T2DM depression. In our study we shall determine the prevalence of depression among T2DM patients in Pakistan. Period: May 2017 to December 2017. Objectives: The objective of this study was to find out the prevalence of depression in Type2 diabetes mellitus patients. Study Design: A cross-sectional study. Setting: Jinnah Post Graduate Medical Centre Karachi. Results: Mean PHQ- Score is 10.83±5.6. 81.9% had PHQ Score > 4. According to PHQ-9 scale, 18.1% (n=30) had no depression, 26.5% (n=44) had moderately severe depression and 3.6% (n=6) had severe depression. In our study females had more severe depression in comparison with male (5.2% vs. 0%). Conclusion: Depression is very common in Pakistan among Type 2 Diabetic patients. Antidepressant has key role to break the vicious cycle of depression and type2 diabetes mellitus diabetes.