It is undeniable that laboratory information is important in healthcare in many ways such as management, planning, and quality improvement. Laboratory diagnosis and laboratory results from each patient are organized from every treatment. These data are useful for retrospective study exploring a relationship between laboratory results and diseases. By doing so, it increases efficiency in diagnosis and quality in laboratory report. Our study will utilize J48 algorithm, a data mining technique to predict abnormality in peripheral blood smear from 1,362 students by using 13 data set of hematological parameters gathered from automated blood cell counter. We found that the decision tree which is created from the algorithm can be used as a practical guideline for RBC morphology prediction by using 4 hematological parameters (MCV, MCH, Hct, and RBC). The average prediction of RBC morphology has true positive, false positive, precision, recall, and accuracy of 0.940, 0.050, 0.945, 0.940, and 0.943, respectively. A newly found paradigm in managing medical laboratory information will be helpful in organizing, researching, and assisting correlation in multiple disciplinary other than medical science which will eventually lead to an improvement in quality of test results and more accurate diagnosis.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency can cause hemolytic anemia in response to oxidative stress. This study was undertaken to study the protective effect of natural curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) with curcuminoid analogs (di-O-demethylcurcumin and mono-O-demethylcurcumin) in healthy and G6PDdeficient red blood cells. After pretreatment blood with the test compounds, 0.75 mM sodium nitrite-oxidized hemolysate was determined for methemoglobin (metHb) formation. Concurrently, the released hemoglobin from 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-challenged cells was measured for hemolysis. We found that most of the compounds reduced metHb formation and oxidative hemolysis in red cells. After pretreatment with curcuminoid analogs, the oxidized hemoglobins were lower than treated with natural compounds. Furthermore, this study showed that demethylcurcumin analogs certainly protect AAPH-induced red cell lysis. This study can be concluded that curcuminoid analogs with different phenol rings possibly have higher antioxidant activity in order to protect the oxidative stress condition, especially in G6PD deficiency.