Animals and viruses have constantly been co-evolving under natural circumstances and pandemic like situations. They harbour harmful viruses which can spread easily. In the recent times we have seen pandemic like situations being created as a result of the spread of deadly and fatal viruses. Coronaviruses (CoVs) are one of the wellrecognized groups of viruses. There are four known genera of Coronavirus family namely, alpha (α), beta (β), gamma (γ), and delta (δ). Animals have been infected with CoVs belonging to all four genera. In the last few decades the world has witnessed an emergence of severe acute respiratory syndromes which had created a pandemic like situation such as SARS CoV, MERS-CoV. We are currently in another pandemic like situation created due to the uncontrolled spread of a similar coronavirus namely SARSCoV-2. These findings are based on a small number of animals and do not indicate whether animals can transmit disease to humans. Several mammals, including cats, dogs, bank voles, ferrets, fruit bats, hamsters, mink, pigs, rabbits, racoon dogs, and white-tailed deer, have been found to be infected naturally by the virus. Certain laboratory discoveries revealed that animals such as cats, ferrets, fruit bats, hamsters, racoon dogs, and white-tailed deer can spread the illness to other animals of the same species. This review article gives insights on the current knowledge about SARS-CoV-2 infection and development in animals on the farm and in domestic community and their impact on society.

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Context Globally Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is the most influential pandemic which affects the human respiratory system. The severity of the disease depends on the interaction between the viral protein and host protein. Spike protein of SARS-CoV-2 interacts with host ACE2 receptor in the presence of TMPRSS serine protease through C-Terminal Domain (CTD). In this research, we studied the effect of mutation on the S-protein stability and functional analysis based on the sequence of SARS CoV-2 delta Indian variants by in silico prediction. Sequences were retrieved from the database and studied mutation and evolutionary relationships. The protein stability is analyzed by predicting intrinsic disorder and I-Mutant v2.0 bioinformatics tool. The functional study of S-protein was conducted using SMART, Protparam, NetPhos, and NetNGlyc. In addition to this analysed the stability of RBD region after mutation. Methods This study explains the effect of mutation on spike proteins and its evolutionary relationship, which is used for the better understanding of SARS CoV-2 variation and diversification. The changes in spike protein promote the evolution of the virus. In the future, a complete analysis of delta variant S protein contributes to effective targeted therapeutic measures.