Background: Antibiotics are one of the most important discoveries in the field of medicine and are widely used in reducing the infections. Irrational antibiotic use may result in increased cost of treatment, drug-drug interactions also cause severe adverse reactions. The objective of the study was to determine average number of antibiotics prescribed per prescription, to identify the indication for which antibiotics were commonly used and to determine the most commonly prescribed antibiotics in a tertiary care hospital.Methods: This was a retrospective observational study. About 300 patients who were prescribed antibiotics were included in the study. The data on antibiotic containing prescriptions from each patient was collected from the inpatient of medicine department. The study was carried out from August 2013 to July 2014.Results: Total 300 prescriptions studied, of which 195 (65%) prescriptions had 2 antibiotics per prescriptions and 105 (35%) prescriptions had more than 2 antibiotics per prescription. It was observed that out of 300 patients, 165 were male (55%) and 135 were female (45%). Fluoroquinolones were most commonly prescribed antibiotics and ciprofloxacin was prescribed mostly. Most of the prescriptions contained polypharmacy. The antibiotics treatment regimens given in most of the patients were without done culture sensitivity test before prescribing, which lead to irrational prescribing.Conclusions: Compliance to adopted treatment guidelines is still a major challenge hence there is an urgent need for following antimicrobial policy.

Background: India is an agrarian country, where pesticides are most widely used in farming. Monsoon dependent agricultural practices are common in India. In present study socioeconomic class and prescribing pattern of commonly used drugs in organophosphate poisoning in indoor setting at tertiary care hospital is evaluated. The aim of the study was to evaluate prescribing trend of drugs and socioeconomic class of patients in organophosphate poisoning in monsoon season.Methods: Prospective observational study was conducted at Medical Intensive Care Unit (MICU) and Medicine Wards for 4 months at 540 bedded tertiary care teaching hospital.Results: Total 64 diagnosed cases were enrolled and analyzed in present study (n=64). Maximum number of cases (57.81%) were male followed by female (42.18%). Most of the cases (37.50%) were from the age group of 21-30 years. 49 (76.56%) patients were of primary intentional poisoning followed by 15 (23.43%) patients of accidental poisoning. Most common drugs prescribed were atropine, pralidoxime, cefotaxime and ranitidine. The average amount of atropine and pralidoxime used per patient/day were 37.89±63.63 mg and 10.07±26.87 gm respectively.Conclusions: Present study revealed that young male adults with low socioeconomic class from rural background were prone for intentional organophosphate poisoning in central India.

Background: To analyze the prescribing patterns of statins a hypolipidemic agents by using HMIS database in outdoor patients at tertiary care teaching hospital of central India.Methods: In this retrospective study Using HMIS database, 1000 prescriptions were analyzed for statin use for various WHO prescription indicators using ATC code of statins, the ratio of prescribed daily dose (PDD) and defined daily dose (DDD) was calculated.Results: Atorvastatin was the only statin which was prescribed as monotherapy (61.1%), whereas as combination with aspirin (38.9%). While analyzing the prescriptions, it was found that patients having abnormal lipid profiles (51.8%) and normal lipid profiles (48.2%) were prescribed atorvastatin. Hypertension with diabetes (37%) was the most common disease followed by hypertension (21.2%) and diabetes mellitus (21%) for which atorvastatin was prescribed. The average number of drugs per prescription were 3.8±1.65.Conclusions: This study depicts the use of atorvastatin in various disease conditions, both as primary and secondary preventive measures. There was no polypharmacy. Such studies should be done to educate the physicians on good prescribing practices and to rationalize use of hypolipidemic drugs.