To the Editor, Autoimmune diseases are characterized by persistent self-reactivity and tissue damage mediated by autoantibodies against self-antigens in which antinuclear antibody (ANA) is a major autoantibody. 1,2 A recent study demonstrated the evidence of autoimmune response with localizing autoantibodies in the airway secretion of asthmatics and that increased IgG to eosinophil peroxide and/or ANA was associated with increased type 2 airway inflammation and eosinophilic
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