Objective: This study aims to observe the analgesic activity of Bangun-bangun (Coleus amboinicus) leaves by induction of pain arising from chemical excitement after exposure to acetic acid.Methods: The effectiveness test of water extract and ethanol extract of Bangun-bangun leaves as an analgesic was measured by comparing the mean of quantitative and the writhing between control and treatment group. In addition, observations on the decrease in inflammatory processes occurred by calculating the reduction in the number of leukocyte migration to the inflammatory area.Result: The decrease of excitatory pain in all treatment Groups (I-IV) were significantly different. The comparison of mean values ± SEM decreased excitatory pain Groups I-II (255.00±22.22; 88.33±14.58), p=0.000. Groups I-III (255.00±22.22; 60.00±10.04), p=0.000 and Groups I-IV (255.00±22.22; 50.83±3.09), p=0.000. On histopathology examination, all treatment groups were significantly different (p=0.006). The comparison of mean value ± SEM decrease number of leukocyte Groups I-II (31.73±5.22; 14.70±3.71), p=0.025. Groups I-III (31.73±5.22; 15.67±3.22), p=0.036 and Groups I-IV (31.73±5.22; 11.77±2.77), p=0.008. However, the comparison of decrease of excitatory of pain and number of leukocyte migration between each group did not show significantly different (p>0.05).Conclusions: This study concluded that the Bangun-bangun leaves both in the form of water extract and ethanol extract proved efficacious as a pain reliever in the mice after induction of acetic acid.

Background: Thyroid cancer is the most common endocrine cancer, and its incidence has continuously increased in the last three decades all over the world. The national prevalence of thyroid cancer has not been recorded. Sex, obesity, and the size of thyroid nodules are the risk factors for thyroid cancer. The aim of this study is to acknowledge the characteristics of thyroid cancer patients in Haji Adam Malik General Hospital. Methods: This is a cross-sectional study and carried out among 97 patients with thyroid cancer at Haji Adam Malik General Hospital from 2013 until 2015. Secondary data were obtained by consecutive sampling techniques using medical records. The inclusion criteria are all patients diagnosed with thyroid cancer based on histopathological analysis. Data were analyzed descriptively using SPSS in percentage.Results: From 97 patients with thyroid cancer, it could be concluded that thyroid cancer is the most frequently diagnosed in the age group of 55–64 years (32.0%). Females were predominant that attributed to 71.1% than males (28.9%). The majority of thyroid cancer was diagnosed at stage IV (39.2%) with the most common histopathological feature of papillary thyroid carcinoma (46,4%). Thyroid cancer patients are usually found with normal BMI (37.1%) and nodule thyroid found with the diameter of ≥4cm (47.4%).Conclusions: In the 55–64-year age female group, thyroid cancer is most diagnosed at stage IV with papillary thyroid carcinoma. Thyroid cancer patients are usually found with normal BMI and the nodule size of ≥4 cm.