Anemia in Indonesia is high. One of two pregnant women suffers from anemia as highest prevalence (85%) was among pregnant women aged 15-24. Maternal anemia are at risk of maternal death and giving birth to premature infant with low birth weight. Among age group 15-24 years, 32% is anemic (both men-women). The prevalence of anemia among women higher than men. The Ministry of Health has determined the consumption of iron tablet as nutrition program among adolescents, but only 8% of female teenagers who received iron tablet. Among adolescents who didn't consume iron tablets, 26% thought that it is unnecessary. The study aims to provide information about the knowledge profile of female adolescents on anemia, and disparity among them in Indonesia. We used the 2012 and 2017 IDHS which was held in all provinces. We analyzed unmarried women aged 15-24 (weighted) descriptively to identify knowledge about anemia from knowledge adolescent reproductive health section. Disparity analysis based on the results of difference percentage of knowledge of anemia according to age group, residence, education level and region. Most female adolescents (77% and 82%) have had heard of anemia. Adolescents who lived in urban areas and aged group 20-24 had higher percentage of having knowledge, and its percentage increased along with the increasing of education. High disparity of knowledge was found by educational background. Highest knowledge of terminology of anemia is blood deficit (69% and 73%). Knowledge of how someone become anemic ranged between 1% and 39%, while more 20% didn't know. Among female adolescent, 94% knew how to treat anemia, as 18% to 63% treated anemia by consuming iron and pills to increase blood. This study indicates that knowledge of female adolescent about anemia still a challenge to reduce prevalence of anemia in Indonesia. Low education as the sub group who need intervention.