Throughout the last decades, cutanous laser surgery has gained popularity among surgeons.This kind of surgery based on the principles of selective photo-thermolysis theory. CO 2 laser selectively target watercontaining tissue, applying controlled tissue vaporization. The tissue ablation and the zone of residual thermal damage is accompanied with a deeper tissue coagulation. A piece of viable intact human skin was taken. Multiple CO 2 laser incisions were carried out with different laser parameters prior to be totally excised, then a histopathological examination were done for these skin samples. Slides were examined under light microscope to evaluate thermal enjury zones, wound edges, and cutanous blood vessles status. Histopathological examination showed that the three thermal zones were chenged wherever the laser parameter changed.

Background: Oral cancer is considered as the sixth-most common malignant neoplasm in the world and the most common type is squamous cell carcinoma (SCC). Akt is a serine/threonine-protein kinase, that acts in the regulation of different signaling downstream pathways, including; proliferation, growth, cell metabolism, angiogenesis and survival. The objective of the present study was to show the expression of p-Akt and its prognostic effect in oral SCC (OSCC). Materials and Methods: A total of 72 cases of OSCC were included in this study; the expression of the Akt gene was done on 4 μm tumor sections using immunohistochemical staining of Akt antibody. Results: Histopathological examination showed that: (43) were GIII, (13) cases were GII, and (16) cases were GI. The positivity of immunohistochemical staining were appear as brown stain. Results showed increase expression of p-Akt in most cases of oral SCC and mean expression about (54.86 ± 31.58), and the expression of p-Akt was increased with the progression of the histological grade of the tumor. Conclusion: High expression of p-Akt and its relation with the progression of tumor grade and invasion of tumor may indicate the relationship between p-Akt expression and aggressiveness and progression of the tumor.