Background: Colonic polyps are slow-growing overgrowth that projects above the surrounding mucosa's of the colon that carry a small risk (< 1%) of becoming malignant. However, because colonic polyps are highly prevalent in the general population (especially with increasing age), they confer an important predisposition to colon cancer and are therefore removed when detected. The distribution of Ki67 and p53 as markers of cell proliferation is very studied in Colorectal Carcinoma. In Iraq, IHC studies to detect p53 & ki-67 expression in GIT malignancy has been conducted. Aims of the study: To detect the expression of p53 & ki-67 in colonic polyps patient by immunohistochemistry. To assess the possible correlation between p53 &ki-67 in colonic polyps patient. To detect the possibility of conversion of pre-malignant colonic polyps to malignant form. Methodology: Fifty cases (27 male and 23 female ) were selected randomly with different types of colonic polyps were included in this study and using descriptive study. The age of patients were ranging from 4 up to 80 years, with mean age of [ 46.3 ] years. Cases were collected from the laboratory of histopathology in Al-sadder Medical city in Al-Najaf and from some private laboratories in the same governorate(Al-Najaf). the data analyzed by qi squared. Result: There is a significant correlation between P53 & age ,p53 & type of polyp also there is a significant correlation between Ki-67& age, Ki-67 & type of colonic polyp .There is a correlation between ki67 & p53. Conclusion: The study represent a trial to understand the probable conversion of polyps to colorectal carcinomaand the role of P53 & KI-67 in genesis of colorectal carcinoma. Recommendation: Screen and follow up to all patient with colonic polyps specially to patient with multiplepolyps. All type of polyps should be removed ,because polypectomy currently constitutes the best strategy forpreventing colorectal cancer