Ulcerative colitis (UC) is a type of inflammatory bowel disease with a high recurrence rate. In this regard, sulfasalazine and immunosuppressive medications are often used for an extended period in clinical practice, but their effectiveness is limited, and they are prone to side effects. Modern research has shown that herbal active ingredients of Traditional Chinese Medicine (TCM), such as polyphenols, alkaloids, quinones, and terpenes, have a promising impact on treating UC via a multi-target mechanism and with low side effects. Poor water solubility and low bioavailability of these agents in the gastrointestinal tract are the most challenging issues in delivering these agents to the target tissues. Researchers have created a variety of oral colon-targeted nano-systems of TCM active ingredients in response to the above formulation issues, which significantly improve the treatment of UC by avoiding gastrointestinal damage, prolonging intestinal retention, and achieving controlled drug release at the lesion site. In order to provide ideas for the oral-targeted treatment of UC with active ingredients from TCM, the research progress of an oral colon-targeted nano-system for the treatment of UC is reviewed in the current study, as well as the research progress of an oral colon-targeted nano-system for the treatment of UC. Keywords: Medicine, Chinese Traditional, Colitis, Ulcerative, Nanoparticle Drug Delivery System.

The nanoparticles of ZnO biosynthesis have distinctive features. many researchers have noted it cute to research in diverse research disciplines due to modern medical applications. different NPS have been estimated for their potential usage in which zinc oxide (ZnO) nps have confirmed to be a viable replacement for treating environmental pollutants, due to their excellent capacity to absorbed rays of UV. The purchase seeds of Trigonella foenum-graecum, clove buds, and leaves of the Salvia officinalis plant from the local market and extracted by hot plate methods. the purpose of the current study was the green synthesis of ZnO nanoparticles (NPS) from the different above extracts followed by a comprehensive characterization and assessment of their biological potential. no-NPS synthesized as such was subjected to characterization employment standard techniques such as particle size and tem. highly stable crystalline NPS with sizes between 32.6 and 142.7 nm were obtained from different plants. These Nps revealed a wide range of biological applications showing antioxidant, moderate α-amylase inhibitors, antibacterial and cytotoxic powers. in addition to the percentage of s. epidermidis and k. pneumonia isolated from human and children was recorded mean (40 and 60.4 %) respectively. The highest antibacterial activity (17±0.10 mm and 18±0.09) was shown by seed salvia Officinalis-mediated ZnO NPS against k and s. epidermidis respectively. on the other aspect the result obtained from using silymarin and the mediated zinc nanoparticles showed limited zone inhibition (15 ± 0.09, 15 ± 0.15, and 8 ± 0.02, 8 ± 0.02) respectively. Among all of the NPS synthesized and used, the effect of seed extract-mediated NPS was found to be most promising for future applications.