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Within the framework of blade aerodynamic design, the maximum aerodynamic efficiency, power production, and minimum thrust force are the targets to obtain. This paper describes an improved optimization framework for blade aerodynamic design under realistic conditions, while considering multiple design parameters. The relationship between the objective function and the design parameters, such as the chord length, maximum chord, and twist angle, were obtained by using the second-order response surface methodology (RSM). Moreover, the identified parameters were organized to optimize the aerodynamic design of the blades. Furthermore, the initial and optimized blade geometries were compared and showed that the performance of the optimized blade improved significantly. In fact, the efficiency was increased by approximately 10%, although its thrust was not varied. In addition, to demonstrate the improvement in the resulting optimized blades, the annual energy production (AEP) was estimated when installed in a specific regional location. The result showed a significant improvement when compared to the baseline blades. This result will be extended to a new perspective approach for a more robust optimal design of a wind turbine blade.

This paper presents the design process and experimental results of a brand new flapping and trailing edge control mechanism for a flapping wing micro air vehicle. The flapping mechanism, whose main components are fabricated from string, is suggested and optimized further by a modified pattern search method. The trailing edge control mechanisms for pitching and rolling moments are designed to be attached onto the present flapping mechanism in a modularized fashion. Prototypes of both mechanisms are fabricated and experimentally tested in order to examine the feasibility of the designs. It is expected that the present flapping mechanism will generate enough lift for the total weight of the vehicle. The present control mechanism is found to be able to supply sufficient control moment.

Hepatitis B viruses (HBV) specifically target the liver, where they efficiently infect quiescent hepatocytes. Thus, HBV virus has potential to be used as vectors for liver-directed gene transfer. We constructed a new HBV-based vector system. It is composed of transfer vector for transferring a foreign gene, green fluorescence protein (GFP) gene, and a helper vector. When the transfer vector and the helper vector were cotransfected into HepG2 cells, the recombinant HBV (rHBV) particles were generated by trans-complementation between two vectors. The rHBV particles carrying the foreign gene were identified by the Southern blot assay. To test gene delivery and the transduction of the rHBV, we infected primary human hepatocytes and immortalized, HepG2 cells with rHBV in vitro. The results using fluorescence microscopy confirmed that the inserted GFP gene was successfully transferred and expressed both in primary human hepatocytes and HepG2 cells.

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