Purpose:The SenseWear™ Armband is an activity monitor developed to improve lifestyle self-monitoring. Currently, few studies assess electronic self-monitoring and weight loss with a lifestyle intervention program. To our knowledge, only one study has used the SenseWear Armband in combination with a lifestyle intervention to improve weight loss, and no studies have evaluated whether a self-monitoring intervention based solely on the armband can promote weight loss. Consequently, the aims of the study were to assess weight loss from electronic self-monitoring, to compare these values to the lifestyle intervention and standard care groups, and to compare weight loss with lifestyle intervention with and without the armband.Patients and methods:We recruited 197 sedentary overweight or obese adults (age, 46.8 ± 10.8 years; BMI, 33.3 ± 5.2 kg/m2) to participate in the 9-month study. Participants were randomized into one of four weight loss groups: 1) the standard care group received a self-directed weight loss program, complete with an evidence-based weight loss manual (standard care, n = 50); 2) a 14-week group-based behavioral weight loss program followed by weekly, biweekly, and monthly telephone counseling calls (GWL, n = 49); 3) the use of the armband to help improve lifestyle self-monitoring (SWA alone, n = 49); or (4) the group-based behavioral weight loss program and follow-up telephone counseling calls plus the armband (GWL + SWA, n = 49). All participants received the evidence-based weight loss manual at baseline. All measures were performed at baseline and months 4 and 9. The primary outcomes were weight loss and waist circumference reduction.Results:This study is a well-designed randomized controlled study powered to detect a 0.5-kg weight loss and 0.6-cm waist circumference reduction in overweight and obese sedentary adults.Conclusion:Innovative technologies are providing lifestyle self-monitoring and weight loss tools. Utilizing these technologies may be an important step in improving the current obesity epidemic.

Abstract:In this study, the authors constructed a novel PLGA [poly(D,L-lactic-co-glycolic acid)]-based polymeric nanocarrier co-encapsulated with doxorubicin (DOX) and magnetic Fe 3 O 4 nanoparticles (MNPs) using a single emulsion evaporation method. The DOX-MNPs showed high entrapment efficiency, and they supported a sustained and steady release of DOX. Moreover, the drug release was pH sensitive, with a faster release rate in an acidic environment than in a neutral environment. In vitro, the DOX-MNPs were easily internalized into murine Lewis lung carcinoma cells and they induced apoptosis. In vivo, the DOX-MNPs showed higher antitumor activity than free DOX solution. Furthermore, the antitumor activity of the DOXMNPs was higher with than without an external magnetic field; they were also associated with smaller tumor volume and a lower metastases incidence rate. This work may provide a new modality for developing an effective drug delivery system.

Submarine hydrothermal manganese deposits are relatively common along the Izu±Bonin ± Mariana (IBM) arc but hydrothermal iron crusts are much less so. The hydrothermal manganese deposits show characteristics typical of submarine hydrothermal manganese deposits found worldwide. Recent hydrothermal manganese deposits associated with active hydrothermal systems occur on seamounts or rifts located $ 5±40 km behind the volcanic front on the Shichito-Iwojima Ridge, IBM. Fossil hydrothermal manganese deposits associated with older hydrothermal systems occur on inactive seamounts located on ridges running parallel to the volcanic front in both forearc and back-arc settings. These fossil hydrothermal manganese deposits are generally overlain by younger hydrogenetic manganese crusts. Differences in minor element composition and in the rare earth element pattern of hydrothermal manganese deposits from the forearc and back-arc settings may re¯ect differences in the nature of substrate rocks or temperature of the hydrothermal¯uids at these locations.

Current best-practice guidelines for credibility assessments in asylum procedures have been criticized for their susceptibility to subjectivity and bias. The current study investigated assumptions underlying credibility assessments in Finnish first-instance asylum procedures and how these assumptions fit with widely accepted psychological science. Following previous research, we categorized assumptions in 56 real-life asylum cases from the Finnish Immigration Service. We found that asylum officials held assumptions about how truthful applicants present their claims, the plausibility of individuals’ behavior in their home countries, and applicants’ knowledge about asylum procedures. The assumptions were only partially in line with psychological science on memory, trauma, intercultural communication, and decision-making. To improve decision-making, training programs for asylum officials should include relevant findings from psychological science. To increase the transparency and combat bias, the written determination letters should also include explicit information about the decision-makers reasoning processes.

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